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Archives de Pédiatrie 16, 3 (2009) 299-305
[Exposure to fine air particles and occurrence of allergic diseases: results of ISAAC-France phase 2].
I. Annesi-Maesano ( ) 1, D. Caillaud, F. Lavaud 2, D. Moreau 3, Y. Le Moullec 4, A. Taytard, G. Pauli, D. Charpin
Annesi-Maesano I, Caillaud D, Lavaud F, Moreau D, Le Moullec Y, Taytard A, Pauli G, Charpin D. Collaboration(s)

To evaluate whether fine air particles could be involved in the occurrence of atopy and allergic diseases, we performed a cross-sectional epidemiological survey involving primary schoolchildren living in six French towns with contrasted air pollution levels. Air pollution was measured during a week in the school yards and by standard air monitoring networks. Children get an examination in school looking for atopic dermatitis and bronchial hyperresponsiveness assessed by a standardized run test. Besides, parents or guardians provided past medical history and environmental data, especially on passive smoking. Overall, 5,338 children, aged 10.4 (+/-0.7) years, coming from 108 different schools and 401 different classes were included in the survey. Taking into account potential confounders, high exposure to proximity PM(2.5) was linked to a higher point prevalence of atopic dermatitis and hyperresponsiveness, to a higher cumulative prevalence of allergic asthma and a higher sensitization rate to common indoor allergens. Thus, these data suggest that chronic exposure to urban fine particles could be a risk factor for atopy, hyperresponsiveness and asthma.
1 :  Epidémiologie des maladies infectieuses et modélisation (ESIM)
INSERM : U707 – Université Pierre et Marie Curie (UPMC) - Paris VI
2 :  Institut de Physique Nucléaire d'Orsay (IPNO)
CNRS : UMR8608 – IN2P3 – Université Paris XI - Paris Sud
3 :  Service de réanimation médicale
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Saint-Louis – Université Paris VII - Paris Diderot
4 :  Laboratoire des Sciences du Génie Chimique (LSGC)
CNRS : UPR6811
Sciences du Vivant/Santé publique et épidémiologie