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Archives de Pédiatrie 16, 3 (2009) 299-305
[Exposure to fine air particles and occurrence of allergic diseases: results of ISAAC-France phase 2].
I. Annesi-Maesano ( ) 1, D. Caillaud, F. Lavaud 2, D. Moreau 3, Y. Le Moullec 4, A. Taytard, G. Pauli, D. Charpin
Annesi-Maesano I, Caillaud D, Lavaud F, Moreau D, Le Moullec Y, Taytard A, Pauli G, Charpin D. Collaboration(s)
(03/2009)

To evaluate whether fine air particles could be involved in the occurrence of atopy and allergic diseases, we performed a cross-sectional epidemiological survey involving primary schoolchildren living in six French towns with contrasted air pollution levels. Air pollution was measured during a week in the school yards and by standard air monitoring networks. Children get an examination in school looking for atopic dermatitis and bronchial hyperresponsiveness assessed by a standardized run test. Besides, parents or guardians provided past medical history and environmental data, especially on passive smoking. Overall, 5,338 children, aged 10.4 (+/-0.7) years, coming from 108 different schools and 401 different classes were included in the survey. Taking into account potential confounders, high exposure to proximity PM(2.5) was linked to a higher point prevalence of atopic dermatitis and hyperresponsiveness, to a higher cumulative prevalence of allergic asthma and a higher sensitization rate to common indoor allergens. Thus, these data suggest that chronic exposure to urban fine particles could be a risk factor for atopy, hyperresponsiveness and asthma.
1 :  Epidémiologie des maladies infectieuses et modélisation (ESIM)
INSERM : U707 – Université Pierre et Marie Curie (UPMC) - Paris VI
2 :  Institut de Physique Nucléaire d'Orsay (IPNO)
CNRS : UMR8608 – IN2P3 – Université Paris XI - Paris Sud
3 :  Service de réanimation médicale
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Saint-Louis – Université Paris VII - Paris Diderot
4 :  Laboratoire des Sciences du Génie Chimique (LSGC)
CNRS : UPR6811
Sciences du Vivant/Santé publique et épidémiologie