Synthesis of pyrrolidine-based analogues of 2-acetamidosugars as N-acetyl glucosaminidase inhibitors
Résumé
A ring-contraction strategy applied to β-azido,γ-hydroxyazepanes yielded after functional group manipulation new tetrahydroxylated pyrrolidines displaying an acetamido moiety, one of these iminosugars demonstrating low micromolar inhibition on N-acetylglucosaminidases.
Origine : Fichiers produits par l'(les) auteur(s)
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