We provide CTA sensitivities to Dark Matter (DM) annihilation in γ-ray lines, from the observation of the Galactic Center (GC) as well as, for the first time, of dwarf Spheroidal galaxies (dSphs). We compare the GC reach with that of dSphs as a function of a putative core radius of the DM distribution, which is itself poorly known. We find that the currently best dSph candidates constitute a more promising target than the GC, for core radii of one to a few kpc. We use the most recent instrument response functions and background estimations by CTA, on top of which we add the diffuse photon component. Our analysis is of particular interest for TeV-scale electroweak multiplets as DM candidates, such as the supersymmetric Wino and the Minimal Dark Matter fiveplet, whose predictions we compare with our projected sensitivities.