Obestatin controls skeletal muscle fiber-type determination

Abstract : Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and-independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile properties and metabolic profile of skeletal muscle through determination of oxidative fiber type. Our data indicate that obestatin regulates Mef2 activity and PGC-1α expression. Both mechanisms result in a shift in muscle metabolism and function. The increase in Mef2 and PGC-1α signaling activates oxidative capacity, whereas Akt/mTOR signaling positively regulates myofiber growth. Taken together, these data indicate that the obestatin signaling acts on muscle fiber-type program in skeletal muscle. The heterogeneous population of muscle fibers determines the plasticity of skeletal muscle.
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Scientific Reports, Nature Publishing Group, 2017, 7, pp.2137. 〈10.1038/s41598-017-02337-4〉
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Icía Santos-Zas, Tania Cid-Díaz, Jessica González-Sánchez, Uxía Gurriarán-Rodriguez, Carlos Seoane-Mosteiro, et al.. Obestatin controls skeletal muscle fiber-type determination. Scientific Reports, Nature Publishing Group, 2017, 7, pp.2137. 〈10.1038/s41598-017-02337-4〉. 〈hal-01534535〉

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