M. Lyon, A. Ducruet, P. Wipf, and J. Lazo, Dual-specificity phosphatases as targets for antineoplastic agents, Nature Reviews Drug Discovery, vol.61, issue.12, p.9612976, 2002.
DOI : 10.1038/nrd963

F. Ducret, C. Turc-baron, P. Pointet, G. Vernin, and O. Skowron, Reninsecreting tumour: about a new diagnosed case during pregnancy], Nephrol Ther, vol.1, p.52261, 2005.

D. Lazar and A. Saltiel, Lipid phosphatases as drug discovery targets for type 2 diabetes, Nature Reviews Drug Discovery, vol.11, issue.4, p.3332342, 2006.
DOI : 10.1021/ol047316m

N. Tonks, Protein tyrosine phosphatases: from genes, to function, to disease, Nature Reviews Molecular Cell Biology, vol.5, issue.11, p.8332846, 2006.
DOI : 10.1038/nrm2039

J. Liu, J. Farmer, . Jr, W. Lane, J. Friedman et al., Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes, Cell, vol.66, issue.4, p.8072815, 1991.
DOI : 10.1016/0092-8674(91)90124-H

Y. Li and J. Casida, Cantharidin-binding protein: identification as protein phosphatase 2A., Proceedings of the National Academy of Sciences, vol.89, issue.24, p.11867211870, 1992.
DOI : 10.1073/pnas.89.24.11867
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50658/pdf

R. Honkanen, Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A, FEBS Letters, vol.23, issue.3, p.2832286, 1993.
DOI : 10.1016/0014-5793(93)80889-3

A. Walsh, A. Cheng, and R. Honkanen, Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A, FEBS Letters, vol.376, issue.3, p.2302234, 1997.
DOI : 10.1016/S0014-5793(97)01210-6

H. Medyouf, H. Alcalde, C. Berthier, M. Guillemin, and N. Santos, Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia, Nature Medicine, vol.10, issue.6, p.7362741, 2007.
DOI : 10.1038/nm1588

S. Martinez-martinez and J. Redondo, Inhibitors of the Calcineurin / NFAT Pathway, Current Medicinal Chemistry, vol.11, issue.8, p.99721007, 2004.
DOI : 10.2174/0929867043455576

V. Ayllon, A. Martinez, A. Garcia, X. Cayla, and A. Rebollo, Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis, Embo J, vol.19, p.223722246, 2000.

F. Dessauge, C. X. Albar, J. Fleischer, A. Ghadiri, and A. , Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis, J Immunol, vol.177, p.244122451, 2006.

A. Signorile, A. Sardanelli, R. Nuzzi, and S. Papa, Serine (threonine) phosphatase(s) acting on cAMP-dependent phosphoproteins in mammalian mitochondria, FEBS Letters, vol.355, issue.1-3, p.91294, 2002.
DOI : 10.1016/S0014-5793(02)02226-3

E. Rubin, S. Mittnacht, E. Villa-moruzzi, and J. Ludlow, Site-specific and temporally-regulated retinoblastoma protein dephosphorylation by protein phosphatase type 1, Oncogene, vol.20, issue.29, p.377623785, 2001.
DOI : 10.1038/sj.onc.1204518
URL : http://www.nature.com/onc/journal/v20/n29/pdf/1204518a.pdf

M. Edwards and R. Thomas, Protein Phosphatase Type 1-Dependent Dephosphorylation of the Retinoblastoma Tumor Suppressor Protein in Ultraviolet-Irradiated Human Skin and Keratinocytes, Journal of Investigative Dermatology, vol.115, issue.1, p.88294, 2000.
DOI : 10.1046/j.1523-1747.2000.00026.x

V. Ayllon, C. X. Garcia, A. Fleischer, A. Rebollo, and A. , The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad, Eur J Immunol, vol.32, p.184721855, 2002.

V. Ayllon, C. X. Garcia, A. Roncal, F. Fernandez, and R. , Bcl-2 targets protein phosphatase 1 alpha to Bad, J Immunol, vol.166, p.734527352, 2001.
DOI : 10.4049/jimmunol.166.12.7345

R. Ray, S. Bhattacharya, and L. Johnson, Protein Phosphatase 2A Regulates Apoptosis in Intestinal Epithelial Cells, Journal of Biological Chemistry, vol.280, issue.35, p.31091231100, 2005.
DOI : 10.1074/jbc.M503041200

K. Singh, C. Communal, and W. Colucci, Inhibition of protein phosphatase 1 induces apoptosis in neonatal rat cardiac myocytes: role of adrenergic receptor stimulation, Basic Research in Cardiology, vol.95, issue.5, p.3892396, 2000.
DOI : 10.1007/s003950070038

H. Kang and I. Choi, Protein Phosphatase 2A Modulates the Proliferation of Human Multiple Myeloma Cells via Regulation of the Production of Reactive Oxygen Intermediates and Anti-Apoptotic Factors, Cellular Immunology, vol.213, issue.1, p.34244, 2001.
DOI : 10.1006/cimm.2001.1861

G. Jan, V. Delorme, V. David, C. Revenu, and A. Rebollo, The toxofilin- actin-PP2C complex of Toxoplasma: identification of interacting domains, Biochem J, vol.401, p.7112719, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00478656

B. Bitler and J. Schroeder, Anti-Cancer Therapies that Utilize Cell Penetrating Peptides, Recent Patents on Anti-Cancer Drug Discovery, vol.5, issue.2, p.992108, 2010.
DOI : 10.2174/157489210790936252

J. Guergnon, F. Dessauge, V. Dominguez, J. Viallet, and S. Bonnefoy, Use of Penetrating Peptides Interacting with PP1/PP2A Proteins As a General Approach for a Drug Phosphatase Technology, Molecular Pharmacology, vol.69, issue.4, p.111521124, 2006.
DOI : 10.1124/mol.105.019364
URL : https://hal.archives-ouvertes.fr/pasteur-00189544

J. Guergnon, F. Dessauge, F. Traincard, C. X. Rebollo, and A. , A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes, Apoptosis, vol.968, issue.23, p.126321273, 2006.
DOI : 10.1007/s10495-006-7702-6

M. Wislez, N. Fujimoto, J. Izzo, A. Hanna, and D. Cody, High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras, Cancer Res, vol.66, p.419824207, 2006.

E. Marangoni, A. Vincent-salomon, N. Auger, A. Degeorges, and F. Assayag, A New Model of Patient Tumor-Derived Breast Cancer Xenografts for Preclinical Assays, Clinical Cancer Research, vol.13, issue.13, p.398923998, 2007.
DOI : 10.1158/1078-0432.CCR-07-0078

L. De-plater, A. Lauge, C. Guyader, M. Poupon, and F. Assayag, Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation, British Journal of Cancer, vol.65, issue.8, p.119221200, 2010.
DOI : 10.1038/8743

F. Nemati, X. Sastre-garau, C. Laurent, J. Couturier, and P. Mariani, Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors, Clinical Cancer Research, vol.16, issue.8, p.235222362, 2010.
DOI : 10.1158/1078-0432.CCR-09-3066

S. Ackler, Y. Xiao, M. Mitten, K. Foster, and A. Oleksijew, ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo, Molecular Cancer Therapeutics, vol.7, issue.10, p.326523274, 2008.
DOI : 10.1158/1535-7163.MCT-08-0268

K. Dorgham, I. Dogan, N. Bitton, C. Parizot, and V. Cardona, Immunogenicity of HIV Type 1 gp120 CD4 Binding Site Phage Mimotopes, AIDS Research and Human Retroviruses, vol.21, issue.1, p.82292, 2005.
DOI : 10.1089/aid.2005.21.82

K. Dorgham, A. Ghadiri, P. Hermand, M. Rodero, and L. Poupel, An engineered CX3CR1 antagonist endowed with anti-inflammatory activity, Journal of Leukocyte Biology, vol.86, issue.4, p.9032911, 2009.
DOI : 10.1189/jlb.0308158

C. Guy, R. Cardiff, and W. Muller, Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease., Molecular and Cellular Biology, vol.12, issue.3, p.9542961, 1992.
DOI : 10.1128/MCB.12.3.954

H. Yamano, K. Ishii, and M. Yanagida, Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation, Embo J, vol.13, p.531025318, 1994.

M. Obeid, Anticancer activity of targeted proapoptotic peptides and chemotherapy is highly improved by targeted cell surface calreticulin-inducer peptides, Molecular Cancer Therapeutics, vol.8, issue.9, p.269322707, 2009.
DOI : 10.1158/1535-7163.MCT-09-0228

G. Kroemer and J. Pouyssegur, Tumor Cell Metabolism: Cancer's Achilles' Heel, Cancer Cell, vol.13, issue.6, p.4722482, 2008.
DOI : 10.1016/j.ccr.2008.05.005
URL : http://doi.org/10.1016/j.ccr.2008.05.005

I. Massodi, G. Bidwell, A. Davis, A. Tausend, and K. Credit, Inhibition of ovarian cancer cell metastasis by a fusion polypeptide Tat-ELP, Clinical & Experimental Metastasis, vol.121, issue.2, 2009.
DOI : 10.1007/s10585-009-9237-z

A. Leduc, J. Trent, J. Wittliff, K. Bramlett, and S. Briggs, Helixstabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions, Proc Natl Acad Sci, vol.100, p.11273211278, 2003.
DOI : 10.1073/pnas.1934759100
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC208747

M. Tan, K. Lan, J. Yao, C. Lu, and M. Sun, Selective Inhibition of ErbB2-Overexpressing Breast Cancer In vivo by a Novel TAT-Based ErbB2-Targeting Signal Transducers and Activators of Transcription 3-Blocking Peptide, Cancer Research, vol.66, issue.7, p.376423772, 2006.
DOI : 10.1158/0008-5472.CAN-05-2747

H. Johansson, S. Andaloussi, and U. Langel, Mimicry of Protein Function with Cell-Penetrating Peptides, Methods Mol Biol, vol.683, p.2332247, 2009.
DOI : 10.1007/978-1-60761-919-2_17

R. Johnson, S. Harrison, and D. Maclean, Therapeutic applications of cellpenetrating peptides, Methods Mol Biol, vol.683, p.5352551, 2009.

S. Jones and J. Howl, Applications of Cell-Penetrating Peptides as Signal Transduction Modulators for the Selective Induction of Apoptosis, Methods Mol Biol, vol.683, p.2912303, 2009.
DOI : 10.1007/978-1-60761-919-2_21

E. Tappan and A. Chamberlin, Activation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme's Regulatory Site, Chemistry & Biology, vol.15, issue.2, p.1672174, 2008.
DOI : 10.1016/j.chembiol.2008.01.005

V. Janssens and J. Goris, Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling, Biochemical Journal, vol.353, issue.3, p.4172439, 2001.
DOI : 10.1042/bj3530417

L. Wong, D. Zhang, C. Chang, and E. Koay, Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis, Experimental Cell Research, vol.316, issue.20, p.338723396, 2010.
DOI : 10.1016/j.yexcr.2010.06.007

S. Liu, G. Dontu, and M. Wicha, Mammary stem cells, self-renewal pathways, and carcinogenesis, Breast Cancer Research, vol.6, issue.Suppl 1, p.86295, 2005.
DOI : 10.1016/j.ccr.2004.08.019
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143566

J. Keen, Q. Zhou, B. Park, C. Pettit, and K. Mack, Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability, J Biol Chem, vol.280, p.29519229524, 2005.
DOI : 10.1074/jbc.m505317200

C. Switzer, L. Ridnour, R. Cheng, A. Sparatore, D. Soldato et al., Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity, Oncogene, vol.7, issue.43, p.383723846, 2009.
DOI : 10.1158/1535-7163.MCT-08-0625
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472634

S. Kim, L. Cao, H. Baek, S. Lim, and C. Li, Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1, Cancer Res, vol.69, p.929129300, 2009.

C. Modak and P. Bryant, Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines, Biochemical and Biophysical Research Communications, vol.368, issue.3, p.8012807, 2008.
DOI : 10.1016/j.bbrc.2008.02.001