A. Abdolahi, G. Williams, C. Benesch, H. Wang, E. Spitzer et al., Damage to the insula leads to decreased nicotine withdrawal during abstinence, Addiction, vol.97, issue.12, pp.1994-2003, 2015.
DOI : 10.1111/add.13061

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644476

A. Adhikari, Distributed circuits underlying anxiety, Frontiers in Behavioral Neuroscience, vol.46, p.112, 2014.
DOI : 10.1016/j.jpsychires.2012.04.013

URL : http://doi.org/10.3389/fnbeh.2014.00112

S. Ahmed and G. Koob, Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point, Science, vol.282, issue.5387, pp.298-300, 1998.
DOI : 10.1126/science.282.5387.298

S. Ahmed and G. Koob, Long-lasting increase in the set point for cocaine self-administration after escalation in rats, Psychopharmacology, vol.146, issue.3, pp.303-312, 1999.
DOI : 10.1007/s002130051121

G. Allen, C. Saper, K. Hurley, and D. Cechetto, Organization of visceral and limbic connections in the insular cortex of the rat, The Journal of Comparative Neurology, vol.159, issue.1, pp.1-16, 1991.
DOI : 10.1002/cne.903110102

R. Alvarez, N. Kirlic, M. Misaki, J. Bodurka, J. Rhudy et al., Increased anterior insula activity in anxious individuals is linked to diminished perceived control. Transl Psychiatry 5:e591 American Psychiatric Association (2013) The diagnostic and statistical manual of mental disorders: DSM 5 Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum, bookpointUS Belin D, Everitt BJ Neuron, vol.57, pp.432-441, 2008.

D. Belin, E. Balado, P. Piazza, and V. Deroche-gamonet, Pattern of Intake and Drug Craving Predict the Development of Cocaine Addiction-like Behavior in Rats, Biological Psychiatry, vol.65, issue.10, pp.863-868, 2009.
DOI : 10.1016/j.biopsych.2008.05.031

D. Belin, N. Berson, E. Balado, P. Piazza, and V. Deroche-gamonet, High-Novelty-Preference Rats are Predisposed to Compulsive Cocaine Self-administration, Neuropsychopharmacology, vol.74, issue.3, pp.569-579, 2011.
DOI : 10.1016/0165-1781(79)90007-6

URL : https://hal.archives-ouvertes.fr/hal-00582971

A. Belin-rauscent, M. Daniel, M. Puaud, B. Jupp, S. Sawiak et al., From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior Neural systems and cueinduced cocaine craving, Mol Psychiatry Bonson KR Neuropsychopharmacology, vol.26, pp.376-386, 2002.

A. Brody, M. Mandelkern, E. London, A. Childress, G. Lee et al., Brain Metabolic Changes During Cigarette Craving, Archives of General Psychiatry, vol.59, issue.12, pp.1162-1172, 2002.
DOI : 10.1001/archpsyc.59.12.1162

J. Carlson, T. Greenberg, D. Rubin, L. Mujica-parodi, M. Lin et al., Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation The agranular and granular insula differentially contribute to gamblinglike behavior on a rat slot machine task: effects of inactivation and local infusion of a dopamine D4 agonist on reward expectancy, Soc Cogn Affect Neurosci Cocker PJ Psychopharmacology, vol.233, pp.3135-3147, 2010.

M. Contreras, F. Ceric, and F. Torrealba, Inactivation of the Interoceptive Insula Disrupts Drug Craving and Malaise Induced by Lithium, Science, vol.86, issue.1, pp.655-658, 2007.
DOI : 10.1016/j.drugalcdep.2006.06.002

C. Cosme, A. Gutman, and R. Lalumiere, The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats, Neuropsychopharmacology, vol.35, issue.10, pp.2425-2433, 2015.
DOI : 10.1038/npp.2015.92

A. Craig, How do you feel? Interoception: the sense of the physiological condition of the body, Nature Reviews Neuroscience, vol.296, issue.8, pp.655-666, 2002.
DOI : 10.1038/nrn894

A. Craig, How do you feel ??? now? The anterior insula and human awareness, Nature Reviews Neuroscience, vol.90, issue.1, pp.59-70, 2009.
DOI : 10.1016/j.neuroimage.2007.05.026

H. Critchley, S. Wiens, P. Rotshtein, A. Ohman, and R. Dolan, Neural systems supporting interoceptive awareness, Nature Neuroscience, vol.7, issue.2, pp.189-195, 2004.
DOI : 10.1038/nn1176

V. Deroche-gamonet, D. Belin, and P. Piazza, Evidence for Addiction-like Behavior in the Rat, Science, vol.305, issue.5686, pp.1014-1017, 2004.
DOI : 10.1126/science.1099020

R. Dilleen, Y. Pelloux, A. Mar, A. Molander, T. Robbins et al., High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats, Psychopharmacology, vol.114, issue.1, pp.89-98, 2012.
DOI : 10.1007/s00213-011-2626-4

V. Droutman, S. Read, and A. Bechara, Revisiting the role of the insula in addiction, Trends in Cognitive Sciences, vol.19, issue.7, pp.414-420, 2015.
DOI : 10.1016/j.tics.2015.05.005

A. Ettenberg, Opponent process properties of self-administered cocaine, Neuroscience & Biobehavioral Reviews, vol.27, issue.8, pp.721-728, 2004.
DOI : 10.1016/j.neubiorev.2003.11.009

A. Ettenberg and T. Geist, Animal model for investigating the anxiogenic effects of self-administered cocaine, Psychopharmacology, vol.23, issue.4, pp.455-461, 1991.
DOI : 10.1007/BF02244244

B. Everitt and T. Robbins, Neural systems of reinforcement for drug addiction: from actions to habits to compulsion, Nature Neuroscience, vol.52, issue.11, pp.1481-1489, 2005.
DOI : 10.1016/j.neuropharm.2004.06.027

B. Everitt and T. Robbins, Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On, Annual Review of Psychology, vol.67, issue.1, pp.23-50, 2016.
DOI : 10.1146/annurev-psych-122414-033457

R. Goldstein, A. Craig, A. Bechara, H. Garavan, A. Childress et al., The Neurocircuitry of Impaired Insight in Drug Addiction, Trends in Cognitive Sciences, vol.13, issue.9, pp.372-380, 2009.
DOI : 10.1016/j.tics.2009.06.004

M. Gray and H. Critchley, Interoceptive Basis to Craving, Neuron, vol.54, issue.2, pp.183-186, 2007.
DOI : 10.1016/j.neuron.2007.03.024

URL : http://doi.org/10.1016/j.neuron.2007.03.024

D. Guzman and A. Ettenberg, Runway self-administration of intracerebroventricular cocaine: evidence of mixed positive and negative drug actions, Behavioural Pharmacology, vol.18, issue.1, pp.53-60, 2007.
DOI : 10.1097/FBP.0b013e3280144ac9

G. Koob, Neurobiology of addiction: a neurocircuitry analysis, The Lancet Psychiatry, vol.3, issue.8, pp.760-773, 2009.
DOI : 10.1016/S2215-0366(16)00104-8

C. Li, N. Zhu, X. Meng, Y. Li, and N. Sui, Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats, Journal of Psychopharmacology, vol.30, issue.9, pp.837-844, 2013.
DOI : 10.1111/j.1369-1600.2012.00443.x

H. Li, L. Chen, P. Li, X. Wang, and H. Zhai, Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze, Behavioural Brain Research, vol.270, pp.256-260, 2014.
DOI : 10.1016/j.bbr.2014.05.017

X. Luo, S. Zhang, S. Hu, S. Bednarski, E. Erdman et al., Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence, Brain, vol.136, issue.4, pp.1231-1244, 2013.
DOI : 10.1093/brain/awt040

S. Mackey and M. Paulus, Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants?, Neuroscience & Biobehavioral Reviews, vol.37, issue.3, pp.300-316, 2013.
DOI : 10.1016/j.neubiorev.2012.12.003

M. Mchugh, C. Demers, J. Braud, R. Briggs, B. Adinoff et al., Striatal-insula circuits in cocaine addiction: implications for impulsivity and relapse risk, The American Journal of Drug and Alcohol Abuse, vol.306, issue.6, pp.424-432, 2013.
DOI : 10.1007/s00213-011-2229-0

R. Mcnamara, J. Dalley, T. Robbins, B. Everitt, and D. Belin, Trait-like impulsivity does not predict escalation of heroin self-administration in the rat, Psychopharmacology, vol.51, issue.Suppl 11, pp.453-464, 2010.
DOI : 10.1007/s00213-010-1974-9

URL : https://hal.archives-ouvertes.fr/hal-00583088

J. Murray, A. Belin-rauscent, M. Simon, C. Giuliano, M. Benoit-marand et al., Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits, Nature Communications, vol.16, p.10088, 2015.
DOI : 10.1111/j.1468-2958.2002.tb00828.x

URL : http://doi.org/10.1038/ncomms10088

N. Naqvi and A. Bechara, The hidden island of addiction: the insula, Trends in Neurosciences, vol.32, issue.1, pp.56-67, 2009.
DOI : 10.1016/j.tins.2008.09.009

N. Naqvi, A. Bechara, D. Rudrauf, H. Damasio, and A. Bechara, The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making Damage to the insula disrupts addiction to cigarette smoking, Brain Struct Funct Naqvi N Science, vol.315, pp.531-534, 2007.

N. Naqvi, N. Gaznick, D. Tranel, and A. Bechara, The insula: a critical neural substrate for craving and drug seeking under conflict and risk, Annals of the New York Academy of Sciences, vol.64, issue.2, 2014.
DOI : 10.1093/cercor/bht218

X. Noel, D. Brevers, and A. Bechara, A neurocognitive approach to understanding the neurobiology of addiction Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions, Curr Opin Neurobiol Parkes SL Balleine BW J Neurosci, vol.33, pp.8753-8763, 2013.

S. Parkes, L. Bradfield, and B. Balleine, Interaction of Insular Cortex and Ventral Striatum Mediates the Effect of Incentive Memory on Choice Between Goal-Directed Actions, Journal of Neuroscience, vol.35, issue.16, pp.6464-6471, 2015.
DOI : 10.1523/JNEUROSCI.4153-14.2015

N. Paterson and A. Markou, Increased motivation for self-administered cocaine after escalated cocaine intake, NeuroReport, vol.14, issue.17, pp.2229-2232, 2003.
DOI : 10.1097/00001756-200312020-00019

M. Paulus and M. Stein, An Insular View of Anxiety, Biological Psychiatry, vol.60, issue.4, pp.383-387, 2006.
DOI : 10.1016/j.biopsych.2006.03.042

M. Paulus and J. Stewart, Interoception and drug addiction, Neuropharmacology, vol.76, pp.342-350, 2014.
DOI : 10.1016/j.neuropharm.2013.07.002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858461

G. Paxinos, C. Watson, Y. Pelloux, J. Murray, and B. Everitt, The rat brain in stereotaxic coordinates, fourth edn Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats, Eur J Neurosci, vol.38, pp.3018-3026, 1998.

A. Pushparaj, A. Kim, M. Musiol, and J. Trigo, Involvement of the rostral agranular insular cortex in nicotine self-administration in rats, Behavioural Brain Research, vol.290, pp.77-83, 2015.
DOI : 10.1016/j.bbr.2015.04.039

S. Reynolds and D. Zahm, Specificity in the Projections of Prefrontal and Insular Cortex to Ventral Striatopallidum and the Extended Amygdala, Journal of Neuroscience, vol.25, issue.50, pp.11757-11767, 2005.
DOI : 10.1523/JNEUROSCI.3432-05.2005

J. Schank, L. Liles, and D. Weinshenker, Norepinephrine Signaling Through ??-Adrenergic Receptors is Critical for Expression of Cocaine-Induced Anxiety, Biological Psychiatry, vol.63, issue.11, pp.1007-1012, 2008.
DOI : 10.1016/j.biopsych.2007.10.018

R. Sinha, New Findings on Biological Factors Predicting Addiction Relapse Vulnerability, Current Psychiatry Reports, vol.315, issue.5811, pp.398-405, 2011.
DOI : 10.1007/s11920-011-0224-0

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674771

S. Specio, S. Wee, O. Dell, L. Boutrel, B. Zorrilla et al., CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats, Psychopharmacology, vol.952, issue.1, pp.473-482, 2008.
DOI : 10.1007/s00213-007-0983-9

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769571

J. Stewart, A. May, T. Poppa, P. Davenport, S. Tapert et al., You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making, Drug and Alcohol Dependence, vol.142, pp.110-119, 2014.
DOI : 10.1016/j.drugalcdep.2014.06.003

Y. Terasawa, M. Shibata, Y. Moriguchi, and S. Umeda, Anterior insular cortex mediates bodily sensibility and social anxiety, Social Cognitive and Affective Neuroscience, vol.8, issue.3, pp.259-266, 2013.
DOI : 10.1093/scan/nss108

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594729

N. Vanhille, A. Belin-rauscent, A. Mar, E. Ducret, and D. Belin, High Locomotor Reactivity to Novelty Is Associated with an Increased Propensity to Choose Saccharin Over Cocaine: New Insights into the Vulnerability to Addiction, Neuropsychopharmacology, vol.57, issue.3, pp.577-589, 2015.
DOI : 10.1901/jeab.1981.35-23

A. Verdejo-garcia and A. Bechara, A somatic marker theory of addiction, Neuropharmacology, vol.56, issue.1, pp.48-62, 2009.
DOI : 10.1016/j.neuropharm.2008.07.035

A. Verdejo-garcia, L. Clark, and B. Dunn, The role of interoception in addiction: A critical review, Neuroscience & Biobehavioral Reviews, vol.36, issue.8, pp.1857-1869, 2012.
DOI : 10.1016/j.neubiorev.2012.05.007

B. Wang, Z. You, E. Oleson, J. Cheer, S. Myal et al., Conditioned Contribution of Peripheral Cocaine Actions to Cocaine Reward and Cocaine-Seeking, Neuropsychopharmacology, vol.27, issue.9, pp.1763-1769, 2013.
DOI : 10.1038/npp.2013.75

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717534

S. Wee, S. Specio, and G. Koob, Effects of Dose and Session Duration on Cocaine Self-Administration in Rats, Journal of Pharmacology and Experimental Therapeutics, vol.320, issue.3, pp.1134-1143, 2007.
DOI : 10.1124/jpet.106.113340

D. Williams and H. Barry, Counter conditioning in an operant conflict situation., Journal of Comparative and Physiological Psychology, vol.61, issue.1, pp.154-156, 1966.
DOI : 10.1037/h0022872

R. Wise, B. Wang, and Z. You, Cocaine Serves as a Peripheral Interoceptive Conditioned Stimulus for Central Glutamate and Dopamine Release, PLoS ONE, vol.40, issue.8, p.2846, 2008.
DOI : 10.1371/journal.pone.0002846.g004

URL : http://doi.org/10.1371/journal.pone.0002846

W. Wu, H. Li, Y. Liu, X. Huang, L. Chen et al., Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats, Psychopharmacology, vol.21, issue.21, 2014.
DOI : 10.1007/s00213-014-3550-1

J. Zaki, J. Davis, and K. Ochsner, Overlapping activity in anterior insula during interoception and emotional experience, NeuroImage, vol.62, issue.1, pp.493-499, 2012.
DOI : 10.1016/j.neuroimage.2012.05.012