C. Van-kooten and J. Banchereau, CD40-CD40 ligand, J Leukoc Biol, vol.67, pp.2-17, 2000.

U. Schonbeck and P. Libby, The CD40/CD154 receptor/ligand dyad, Cell Mol Life Sci, vol.58, pp.4-43, 2001.

G. Hassan, Y. Merhi, and W. Mourad, CD154 and its receptors in inflammatory vascular pathologies, Trends in Immunology, vol.30, issue.4, pp.165-172, 2009.
DOI : 10.1016/j.it.2009.01.004

P. Andre, K. Prasad, C. Denis, M. He, and J. Papalia, CD40L stabilizes arterial thrombi by a ??3 integrin???dependent mechanism, Nature Medicine, vol.8, issue.3, pp.247-252, 2002.
DOI : 10.1038/nm0302-247

C. Leveille, M. Bouillon, W. Guo, J. Bolduc, and E. Sharif-askari, CD40 Ligand Binds to ?5beta1 Integrin and Triggers Cell Signaling, Journal of Biological Chemistry, vol.282, issue.8, pp.5143-5151, 2007.
DOI : 10.1074/jbc.M608342200

A. Zirlik, C. Maier, N. Gerdes, L. Macfarlane, and J. Soosairajah, CD40 Ligand Mediates Inflammation Independently of CD40 by Interaction With Mac-1, Circulation, vol.115, issue.12, pp.1571-1580, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.683201

G. Hassan, Y. Merhi, and W. Mourad, CD40 Ligand: A neo-inflammatory molecule in vascular diseases, Immunobiology, vol.217, issue.5, 2011.
DOI : 10.1016/j.imbio.2011.03.010

G. Hassan, R. M. Léveillé, C. Nadiri, A. Jundi, and M. , Implication of CD154/CD40 Interaction in Healthy and Autoimmune Responses, Current Immunology Reviews, vol.5, issue.4, pp.285-299, 2009.
DOI : 10.2174/157339509789503989

M. Cayabyab, J. Phillips, and L. Lanier, CD40 preferentially costimulates activation of CD4+ T lymphocytes, J Immunol, vol.152, pp.1523-1531, 1994.

M. Blotta, J. Marshall, R. Dekruyff, and D. Umetsu, Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis, J Immunol, vol.156, pp.3133-3140, 1996.

P. Blair, J. Riley, D. Harlan, R. Abe, and D. Tadaki, T Cell Activation Response That Results in Secretion of Immunomodulatory Cytokines and Apoptosis, The Journal of Experimental Medicine, vol.358, issue.4, pp.651-660, 2000.
DOI : 10.1038/15256

B. Brenner, U. Koppenhoefer, A. Lepple-wienhues, H. Grassme, and C. Muller, The CD40 Ligand Directly Activates T-Lymphocytes via Tyrosine Phosphorylation Dependent PKC Activation, Biochemical and Biophysical Research Communications, vol.239, issue.1, pp.11-17, 1997.
DOI : 10.1006/bbrc.1997.7415

B. Brenner, U. Koppenhoefer, H. Grassme, J. Kun, and F. Lang, Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes, FEBS Letters, vol.22, issue.3, pp.301-306, 1997.
DOI : 10.1016/S0014-5793(97)01306-9

S. Mikolajczak, B. Ma, T. Yoshida, R. Yoshida, and D. Kelvin, The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells, The Journal of Experimental Medicine, vol.160, issue.7, pp.1025-1031, 2004.
DOI : 10.1074/jbc.274.16.11310

E. Fakhry, Y. Alturaihi, H. Diallo, D. Merhi, Y. Mourad et al., Critical role of lipid rafts in CD154-mediated T cell signaling, European Journal of Immunology, vol.279, issue.3, pp.770-779, 2010.
DOI : 10.1002/eji.200939646

K. Simons and D. Toomre, Lipid rafts and signal transduction, Nature Reviews Molecular Cell Biology, vol.1, issue.1, pp.31-39, 2000.
DOI : 10.1038/35036052

C. Reyes-moreno, E. Sharif-askari, J. Girouard, C. Leveille, and M. Jundi, Requirement of Oxidation-dependent CD40 Homodimers for CD154/CD40 Bidirectional Signaling, Journal of Biological Chemistry, vol.282, issue.27, pp.19473-19480, 2007.
DOI : 10.1074/jbc.M701076200

A. Nadiri, M. Polyak, M. Jundi, H. Alturaihi, and C. Reyes-moreno, CD40 translocation to lipid rafts: Signaling requirements and downstream biological events, European Journal of Immunology, vol.77, issue.8, pp.2358-2367, 2011.
DOI : 10.1002/eji.201041143

M. Bouillon, E. Fakhry, Y. Girouard, J. Khalil, H. Thibodeau et al., Lipid Raft-dependent and -independent Signaling through HLA-DR Molecules, Journal of Biological Chemistry, vol.278, issue.9, pp.7099-7107, 2003.
DOI : 10.1074/jbc.M211566200

H. Grassme, J. Bock, J. Kun, and E. Gulbins, Clustering of CD40 Ligand Is Required to Form a Functional Contact with CD40, Journal of Biological Chemistry, vol.277, issue.33, pp.30289-30299, 2002.
DOI : 10.1074/jbc.M200494200

L. Pike and J. Miller, Cholesterol Depletion Delocalizes Phosphatidylinositol Bisphosphate and Inhibits Hormone-stimulated Phosphatidylinositol Turnover, Journal of Biological Chemistry, vol.273, issue.35, pp.22298-22304, 1998.
DOI : 10.1074/jbc.273.35.22298

D. Paolo, G. , D. Camilli, and P. , Phosphoinositides in cell regulation and membrane dynamics, Nature, vol.26, issue.7112, pp.651-657, 2006.
DOI : 10.1038/nature05185

S. Mahammad and I. Parmryd, Cholesterol homeostasis in T cells. Methyl-??-cyclodextrin treatment results in equal loss of cholesterol from Triton X-100 soluble and insoluble fractions, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1778, issue.5, pp.1251-1258, 2008.
DOI : 10.1016/j.bbamem.2008.02.010

P. Kabouridis, J. Janzen, A. Magee, and S. Ley, Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes, European Journal of Immunology, vol.30, issue.3, pp.954-963, 2000.
DOI : 10.1002/1521-4141(200003)30:3<954::AID-IMMU954>3.0.CO;2-Y

P. Janes, S. Ley, and A. Magee, Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor, The Journal of Cell Biology, vol.18, issue.2, pp.447-461, 1999.
DOI : 10.1016/S0092-8674(00)80901-0

C. Langlet, A. Bernard, P. Drevot, and H. He, Membrane rafts and signaling by the multichain immune recognition receptors, Current Opinion in Immunology, vol.12, issue.3, pp.250-255, 2000.
DOI : 10.1016/S0952-7915(00)00084-4

P. Cheng, M. Dykstra, R. Mitchell, and S. Pierce, A Role for Lipid Rafts in B Cell Antigen Receptor Signaling and Antigen Targeting, The Journal of Experimental Medicine, vol.155, issue.11, pp.1549-1560, 1999.
DOI : 10.1016/S1074-7613(00)80024-2

D. Brown, Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals, Physiology, vol.21, issue.6, pp.430-439, 2006.
DOI : 10.1152/physiol.00032.2006

A. Perschl, J. Lesley, N. English, R. Hyman, and I. Trowbridge, Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts, J Cell Sci, vol.108, pp.1033-1041, 1995.

J. Bock and E. Gulbins, The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts, FEBS Letters, vol.6, issue.1-3, pp.169-174, 2003.
DOI : 10.1016/S0014-5793(02)03784-5

S. Kiani-alikhan, P. Yong, K. Gilmour, D. Grosse-kreul, and E. Davies, Phenotypic Heterogeneity in a Family with a CD40 Ligand Intracellular Domain Mutation, Journal of Clinical Immunology, vol.29, issue.1, 2011.
DOI : 10.1007/s10875-011-9607-6

C. Montixi, C. Langlet, A. Bernard, J. Thimonier, and C. Dubois, Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains, The EMBO Journal, vol.17, issue.18, pp.5334-5348, 1998.
DOI : 10.1093/emboj/17.18.5334

R. Xavier, T. Brennan, Q. Li, C. Mccormack, and B. Seed, Membrane Compartmentation Is Required for Efficient T Cell Activation, Immunity, vol.8, issue.6, pp.723-732, 1998.
DOI : 10.1016/S1074-7613(00)80577-4
URL : http://doi.org/10.1016/s1074-7613(00)80577-4

P. Kabouridis and E. Jury, Lipid rafts and T-lymphocyte function: Implications for autoimmunity, FEBS Letters, vol.275, issue.27, pp.3711-3718, 2008.
DOI : 10.1016/j.febslet.2008.10.006
URL : http://doi.org/10.1016/j.febslet.2008.10.006

S. Matsuda, T. Moriguchi, S. Koyasu, and E. Nishida, T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A, Journal of Biological Chemistry, vol.273, issue.20, pp.12378-12382, 1998.
DOI : 10.1074/jbc.273.20.12378

T. Yu, Y. Liu, Y. Tan, Y. Jiang, and X. Zheng, Shock Waves Increase T-cell Proliferation or IL-2 Expression by Activating p38 MAP Kinase, Acta Biochimica et Biophysica Sinica, vol.36, issue.11, pp.741-748, 2004.
DOI : 10.1093/abbs/36.11.741

Y. Pei, P. Zhu, Y. Dang, J. Wu, and X. Yang, Nuclear Export of NF90 to Stabilize IL-2 mRNA Is Mediated by AKT-Dependent Phosphorylation at Ser647 in Response to CD28 Costimulation, The Journal of Immunology, vol.180, issue.1, pp.222-229, 2008.
DOI : 10.4049/jimmunol.180.1.222