A. Hollander, A. Black, J. Bennett, and F. Cremers, Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies, Journal of Clinical Investigation, vol.120, issue.9, pp.3042-3053, 2010.
DOI : 10.1172/JCI42258

E. Stone, J. Fingert, W. Alward, T. Nguyen, and J. Polansky, Identification of a Gene That Causes Primary Open Angle Glaucoma, Science, vol.275, issue.5300, pp.668-670, 1997.
DOI : 10.1126/science.275.5300.668

D. Dalkara, K. Kolstad, N. Caporale, M. Visel, and R. Klimczak, Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous, Molecular Therapy, vol.17, issue.12, pp.2096-2102, 2009.
DOI : 10.1038/mt.2009.181

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814392

K. Kolstad, D. Dalkara, K. Guerin, M. Visel, and N. Hoffmann, Changes in Adeno-Associated Virus-Mediated Gene Delivery in Retinal Degeneration, Human Gene Therapy, vol.21, issue.5, pp.571-578, 2010.
DOI : 10.1089/hum.2009.194

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143418

T. Park, Z. Wu, S. Kjellstrom, Y. Zeng, and R. Bush, Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse, Gene Therapy, vol.102, issue.7, pp.916-926, 2009.
DOI : 10.1038/gt.2009.61

A. Bemelmans, S. Bonnel, L. Houhou, N. Dufour, and E. Nandrot, Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter, The Journal of Gene Medicine, vol.43, issue.10, pp.1367-1374, 2005.
DOI : 10.1002/jgm.788

URL : https://hal.archives-ouvertes.fr/hal-00187439

R. Yanez-munoz, K. Balaggan, A. Macneil, S. Howe, and M. Schmidt, Effective gene therapy with nonintegrating lentiviral vectors, Nature Medicine, vol.25, issue.3, pp.348-353, 2006.
DOI : 10.1038/nm1365

G. Acland, G. Aguirre, J. Ray, Q. Zhang, and T. Aleman, Gene therapy restores vision in a canine model of childhood blindness, Nature Genetics, vol.28, issue.1, pp.92-95, 2001.
DOI : 10.1038/ng0501-92

S. Boye, S. Boye, J. Pang, R. Ryals, and D. Everhart, Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse, PLoS ONE, vol.361, issue.6, p.11306, 2010.
DOI : 10.1371/journal.pone.0011306.s001

X. Sun, B. Pawlyk, X. Xu, X. Liu, and O. Bulgakov, Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations, Gene Therapy, vol.72, issue.1, pp.117-131, 2010.
DOI : 10.1016/0278-4327(88)90025-9

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804971

P. Buch, J. Bainbridge, and R. Ali, AAV-mediated gene therapy for retinal disorders: from mouse to man, Gene Therapy, vol.30, issue.11, pp.849-857, 2008.
DOI : 10.1167/iovs.06-1501

J. Bainbridge, A. Smith, S. Barker, R. S. Henderson, and R. , Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis, New England Journal of Medicine, vol.358, issue.21, pp.2231-2239, 2008.
DOI : 10.1056/NEJMoa0802268

A. Maguire, F. Simonelli, E. Pierce, E. Pugh, . Jr et al., Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis, New England Journal of Medicine, vol.358, issue.21, pp.2240-2248, 2008.
DOI : 10.1056/NEJMoa0802315

W. Hauswirth, T. Aleman, S. Kaushal, A. Cideciyan, and S. Schwartz, Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial, Human Gene Therapy, vol.19, issue.10, pp.979-990, 2008.
DOI : 10.1089/hum.2008.107

J. Bennett, J. Wilson, D. Sun, B. Forbes, and A. Maguire, Adenovirus vectormediated in vivo gene transfer into adult murine retina, Invest Ophthalmol Vis Sci, vol.35, pp.2535-2542, 1994.

L. Meur, G. Stieger, K. Smith, A. Weber, M. Deschamps et al., Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium, Gene Therapy, vol.97, issue.4, pp.292-303, 2007.
DOI : 10.1038/sj.gt.3302861

L. Cheng, M. Toyoguchi, D. Looney, J. Lee, and M. Davidson, EFFICIENT GENE TRANSFER TO RETINAL PIGMENT EPITHELIUM CELLS WITH LONG-TERM EXPRESSION, Retina, vol.25, issue.2, pp.193-201, 2005.
DOI : 10.1097/00006982-200502000-00013

J. Pang, S. Boye, A. Kumar, A. Dinculescu, and W. Deng, Mouse Containing a Recessive PDE? Mutation, Investigative Opthalmology & Visual Science, vol.49, issue.10, pp.4278-4283, 2008.
DOI : 10.1167/iovs.07-1622

H. Abouzeid and T. Wolfensberger, Macular recovery after retinal detachment, Acta Ophthalmologica Scandinavica, vol.178, issue.5, pp.597-605, 2006.
DOI : 10.1111/j.1600-0420.2006.00676.x

J. Bainbridge and R. Ali, Success in sight: The eyes have it! Ocular gene therapy trials for LCA look promising, Gene Therapy, vol.15, issue.17, pp.1191-1192, 2008.
DOI : 10.1056/NEJMoa0802315

F. Simonelli, A. Maguire, F. Testa, E. Pierce, and F. Mingozzi, Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration, Molecular Therapy, vol.18, issue.3, pp.643-650, 2010.
DOI : 10.1038/mt.2009.277

A. Bird, Therapeutic targets in age-related macular disease, Journal of Clinical Investigation, vol.120, issue.9, pp.3033-3041, 2010.
DOI : 10.1172/JCI42437

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929720

J. Cunha-vaz, The blood-ocular barriers: past, present, and future, Documenta Ophthalmologica, vol.32, issue.1-2, pp.149-157, 1997.
DOI : 10.1007/BF02569055

S. Duque, B. Joussemet, C. Riviere, T. Marais, and L. Dubreil, Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons, Molecular Therapy, vol.17, issue.7, pp.1187-1196, 2009.
DOI : 10.1038/mt.2009.71

K. Foust, E. Nurre, C. Montgomery, A. Hernandez, and C. Chan, Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes, Nature Biotechnology, vol.94, issue.1, pp.59-65, 2009.
DOI : 10.1038/nbt.1515

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895694

E. Dominguez, T. Marais, N. Chatauret, S. Benkhelifa-ziyyat, and S. Duque, Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice, Human Molecular Genetics, vol.20, issue.4, pp.681-693, 2011.
DOI : 10.1093/hmg/ddq514

K. Foust, X. Wang, V. Mcgovern, L. Braun, and A. Bevan, Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN, Nature Biotechnology, vol.9, issue.3, pp.271-274, 2010.
DOI : 10.1038/nbt.1610

C. Valori, K. Ning, M. Wyles, R. Mead, and A. Grierson, Systemic Delivery of scAAV9 Expressing SMN Prolongs Survival in a Model of Spinal Muscular Atrophy, Science Translational Medicine, vol.28, issue.3, pp.35-42, 2010.
DOI : 10.1038/nbt.1610

M. Passini and S. Cheng, Prospects for the gene therapy of spinal muscular atrophy, Trends in Molecular Medicine, vol.17, issue.5, pp.259-265, 2011.
DOI : 10.1016/j.molmed.2011.01.002

S. Gray, V. Matagne, L. Bachaboina, S. Yadav, and S. Ojeda, Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates, Molecular Therapy, vol.19, issue.6, pp.1058-1069, 2011.
DOI : 10.1038/mt.2011.72

N. Kotchey, K. Adachi, M. Zahid, K. Inagaki, and R. Charan, A Potential Role of Distinctively Delayed Blood Clearance of Recombinant Adeno-associated Virus Serotype 9 in Robust Cardiac Transduction, Molecular Therapy, vol.19, issue.6, pp.1079-1089, 2011.
DOI : 10.1038/mt.2011.3

H. Petrs-silva, A. Dinculescu, Q. Li, S. Min, and V. Chiodo, High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors, Molecular Therapy, vol.17, issue.3, pp.463-471, 2009.
DOI : 10.1038/mt.2008.269

F. Nadal-nicolas, M. Jimenez-lopez, P. Sobrado-calvo, L. Nieto-lopez, and I. Canovas-martinez, Brn3a as a Marker of Retinal Ganglion Cells: Qualitative and Quantitative Time Course Studies in Nai?ve and Optic Nerve?Injured Retinas, Investigative Opthalmology & Visual Science, vol.50, issue.8, pp.3860-3868, 2009.
DOI : 10.1167/iovs.08-3267

I. Liu, J. Chen, L. Ploder, D. Vidgen, and D. Van-der-kooy, Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer, Neuron, vol.13, issue.2, pp.377-393, 1994.
DOI : 10.1016/0896-6273(94)90354-9

K. Inagaki, S. Fuess, T. Storm, G. Gibson, and C. Mctiernan, Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8, Molecular Therapy, vol.14, issue.1, pp.45-53, 2006.
DOI : 10.1016/j.ymthe.2006.03.014

C. Pacak, C. Mah, B. Thattaliyath, T. Conlon, and M. Lewis, Recombinant Adeno-Associated Virus Serotype 9 Leads to Preferential Cardiac Transduction In Vivo, Circulation Research, vol.99, issue.4, pp.3-9, 2006.
DOI : 10.1161/01.RES.0000237661.18885.f6

C. Zincarelli, S. Soltys, G. Rengo, and J. Rabinowitz, Analysis of AAV Serotypes 1???9 Mediated Gene Expression and Tropism in Mice After Systemic Injection, Molecular Therapy, vol.16, issue.6, pp.1073-1080, 2008.
DOI : 10.1038/mt.2008.76

B. Bostick, A. Ghosh, Y. Yue, C. Long, and D. Duan, Systemic AAV-9 transduction in mice is influenced by animal age but not by the route of administration, Gene Therapy, vol.14, issue.22, pp.1605-1609, 2007.
DOI : 10.1089/hum.2006.17.601

B. Joussemet, B. Belbellaa, A. Mendes-madeira, T. Bucher, and D. Briot-nivard, Neonatal systemic delivery of scAAV9 in rodents and large animals results in gene transfer to RPE cells in the retina, Experimental Eye Research, vol.93, issue.4, pp.491-502, 2011.
DOI : 10.1016/j.exer.2011.06.012

A. Rahim, A. Wong, K. Hoefer, S. Buckley, and C. Mattar, Intravenous administration of AAV2/9 to the fetal and neonatal mouse leads to differential targeting of CNS cell types and extensive transduction of the nervous system, The FASEB Journal, vol.25, issue.10, pp.3505-3518, 2011.
DOI : 10.1096/fj.11-182311

D. Dalkara, L. Byrne, T. Lee, N. Hoffmann, and D. Schaffer, Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9, Gene Therapy, vol.184, issue.2, 2011.
DOI : 10.1038/nprot.2006.207

W. Aartsen, K. Van-cleef, L. Pellissier, R. Hoek, and R. Vos, GFAP-Driven GFP Expression in Activated Mouse M?ller Glial Cells Aligning Retinal Blood Vessels Following Intravitreal Injection of AAV2/6 Vectors, PLoS ONE, vol.15, issue.8, p.12387, 2010.
DOI : 10.1371/journal.pone.0012387.s001

R. Klein, R. Dayton, J. Tatom, K. Henderson, and P. Henning, AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method, Molecular Therapy, vol.16, issue.1, pp.89-96, 2008.
DOI : 10.1038/sj.mt.6300331

C. Hayworth, J. Rojas, and F. Gonzalez-lima, Transgenic Mice Expressing Cyan Fluorescent Protein as a Reporter Strain to Detect the Effects of Rotenone Toxicity on Retinal Ganglion Cells, Journal of Toxicology and Environmental Health, Part A, vol.21, issue.2, pp.1582-1592, 2008.
DOI : 10.1007/BF03033307

E. Tamm, Myocilin and glaucoma: facts and ideas, Progress in Retinal and Eye Research, vol.21, issue.4, pp.395-428, 2002.
DOI : 10.1016/S1350-9462(02)00010-1

C. Pacak, Y. Sakai, B. Thattaliyath, C. Mah, and B. Byrne, Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice, Genetic Vaccines and Therapy, vol.6, issue.1, p.13, 2008.
DOI : 10.1186/1479-0556-6-13

R. Xu, C. Janson, M. Mastakov, P. Lawlor, and D. Young, Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes, Gene Therapy, vol.8, issue.17, pp.1323-1332, 2001.
DOI : 10.1038/sj.gt.3301529

H. Miyoshi, M. Takahashi, F. Gage, and I. Verma, Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector, Proceedings of the National Academy of Sciences, vol.9, issue.1, pp.10319-10323, 1997.
DOI : 10.1016/0896-6273(92)90226-4

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23360/pdf

D. Williams, Usher syndrome: Animal models, retinal function of Usher proteins, and prospects for gene therapy, Vision Research, vol.48, issue.3, pp.433-441, 2008.
DOI : 10.1016/j.visres.2007.08.015

D. Simons, S. Boye, W. Hauswirth, and S. Wu, Gene therapy prevents photoreceptor death and preserves retinal function in a Bardet-Biedl syndrome mouse model, Proceedings of the National Academy of Sciences, vol.13, issue.6, pp.6276-6281, 2011.
DOI : 10.1016/j.ymthe.2006.03.005

F. Bock, J. Onderka, T. Dietrich, B. Bachmann, and F. Kruse, Bevacizumab as a Potent Inhibitor of Inflammatory Corneal Angiogenesis and Lymphangiogenesis, Investigative Opthalmology & Visual Science, vol.48, issue.6, pp.2545-2552, 2007.
DOI : 10.1167/iovs.06-0570

P. Bishop, M. Takanosu, L. Goff, M. Mayne, and R. , The role of the posterior ciliary body in the biosynthesis of vitreous humour, Eye, vol.16, issue.4, pp.454-460, 2002.
DOI : 10.1038/sj.eye.6700199