Stereoselective access to trisubstituted fluorinated alkenyl thioethers
Résumé
We report the first copper-catalyzed olefinic ethoxy carbonyl difluoromethylation of alkenyl thioethers via direct C–H bond functionalization using BrCF2COOEt. The developed methodology allows the preparation of trisubstituted olefins with a controlled stereochemistry. A mechanistic study is reported and a radical mechanism is revealed.
Origine : Fichiers produits par l'(les) auteur(s)
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