Variable habitat conditions drive species covariation in the human microbiota

Abstract : Two species with similar resource requirements respond in a characteristic way to variations in their habitat—their abundances rise and fall in concert. We use this idea to learn how bacterial populations in the microbiota respond to habitat conditions that vary from person-to-person across the human population. Our mathematical framework shows that habitat fluctuations are sufficient for explaining intra-bodysite correlations in relative species abundances from the Human Microbiome Project. We explicitly show that the relative abundances of closely related species are positively correlated and can be predicted from taxonomic relationships. We identify a small set of functional pathways related to metabolism and maintenance of the cell wall that form the basis of a common resource sharing niche space of the human microbiota.
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PLoS Computational Biology, Public Library of Science, 2017, 13 (4), pp.e1005435. <10.1371/journal.pcbi.1005435>
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Dernière modification le : mercredi 21 juin 2017 - 01:14:04

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Charles K. Fisher, Thierry Mora, Aleksandra M. Walczak. Variable habitat conditions drive species covariation in the human microbiota. PLoS Computational Biology, Public Library of Science, 2017, 13 (4), pp.e1005435. <10.1371/journal.pcbi.1005435>. <hal-01541908>

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