A podocyte view of membranous nephropathy: from Heymann nephritis to the childhood human disease

Abstract : Membranous nephropathy (MN) is characterized by an accumulation of immune deposits on the subepithelial side of the glomerular basement membrane, which results in complement activation and proteinuria. Since 2002, several major antigens of the podocyte have been identified in human MN, the first one being neutral endopeptidase (NEP), the alloantigen involved in neonatal cases of MN that occur in newborns from NEP-deficient mothers. This discovery opened the field to the major advances that have occurred since then in the pathophysiology and treatment of MN. It is remarkable that experimental models such as Heymann nephritis and cationic bovine serum albumin-induced MN in the rabbit predicted the pathomechanisms of the human glomerulopathy. The podocyte is at the center of the pathogenesis of MN either by providing a source of endogenous antigens or by creating an environment favorable to deposition and accumulation of immune complexes containing exogenous (non-podocyte) antigens. The podocyte is also a victim of complement activation and antibody blocking activity against enzymes or receptors. A search for innovative drugs aimed at protecting this cell against complement activation and the effects of prolonged ER stress has become a priority.
Type de document :
Article dans une revue
Pflügers Archiv European Journal of Physiology, Springer Verlag (Germany), 2017, pp.1-9. 〈10.1007/s00424-017-2007-x〉
Liste complète des métadonnées

Littérature citée [73 références]  Voir  Masquer  Télécharger

http://hal.upmc.fr/hal-01543682
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : mercredi 21 juin 2017 - 11:01:06
Dernière modification le : vendredi 23 juin 2017 - 01:11:07
Document(s) archivé(s) le : samedi 16 décembre 2017 - 01:35:02

Fichier

Ronco_2017_A_podocyte_view_of....
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Pierre Ronco, Hanna Debiec. A podocyte view of membranous nephropathy: from Heymann nephritis to the childhood human disease. Pflügers Archiv European Journal of Physiology, Springer Verlag (Germany), 2017, pp.1-9. 〈10.1007/s00424-017-2007-x〉. 〈hal-01543682〉

Partager

Métriques

Consultations de la notice

78

Téléchargements de fichiers

3