Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression

Abstract : Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children. Methods: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA. Results: Among the children studied, the median total HIV DNA level was 445 copies/106 cells (IQR = 187–914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18–0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation (P = 0.01). Overall, eight HIV-1 seroreversions were identified. Conclusions: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
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Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2017, 72 (4), pp.1147-1151. 〈10.1093/jac/dkw537〉
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Josephine Brice, Mariam Sylla, Sophie Sayon, Fatoumata Telly, Djeneba Bocar-Fofana, et al.. Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2017, 72 (4), pp.1147-1151. 〈10.1093/jac/dkw537〉. 〈hal-01548242〉

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