J. H. Barlow, R. B. Faryabi, E. Callé-n, N. Wong, A. Malhowski et al., Identification of Early Replicating Fragile Sites that Contribute to Genome Instability, Cell, vol.152, issue.3, pp.620-632, 2013.
DOI : 10.1016/j.cell.2013.01.006

R. Beroukhim, C. H. Mermel, D. Porter, G. Wei, S. Raychaudhuri et al., The landscape of somatic copy-number alteration across human cancers, Nature, vol.21, issue.7283, pp.899-905, 2010.
DOI : 10.4161/cc.6.6.4035

G. R. Bignell, C. D. Greenman, H. Davies, A. P. Butler, S. Edkins et al., Signatures of mutation and selection in the cancer genome, Nature, vol.18, issue.7283, pp.893-898, 2010.
DOI : 10.1038/nm1512

S. De and F. Michor, DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes, Nature Biotechnology, vol.474, issue.12, pp.1103-1108, 2011.
DOI : 10.1093/bib/bbq016
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923360

A. Dereli-o-¨-z, G. Versini, and T. D. Halazonetis, Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress, Molecular Oncology, vol.63, issue.4, pp.308-314, 2011.
DOI : 10.1093/emboj/19.12.2775

S. Djebali, C. A. Davis, A. Merkel, A. Dobin, T. Lassmann et al., Landscape of transcription in human cells, Nature, vol.474, issue.7414, pp.101-108, 2012.
DOI : 10.1038/nature10006
URL : https://hal.archives-ouvertes.fr/hal-01216755

S. G. Durkin and T. W. Glover, Chromosome Fragile Sites, Annual Review of Genetics, vol.41, issue.1, pp.169-192, 2007.
DOI : 10.1146/annurev.genet.41.042007.165900

R. S. Hansen, S. Thomas, R. Sandstrom, T. K. Canfield, R. E. Thurman et al., Sequencing newly replicated DNA reveals widespread plasticity in human replication timing, Proc. Natl. Acad. Sci. USA, pp.139-144, 2010.
DOI : 10.1038/nature03479
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806781

A. Helmrich, M. Ballarino, T. , and L. , Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes, Molecular Cell, vol.44, issue.6, pp.966-977, 2011.
DOI : 10.1016/j.molcel.2011.10.013
URL : http://doi.org/10.1016/j.molcel.2011.10.013

D. Iliopoulos, G. Guler, S. Y. Han, T. Druck, M. Ottey et al., Roles of FHIT and WWOX fragile genes in cancer, Cancer Letters, vol.232, issue.1, pp.27-36, 2006.
DOI : 10.1016/j.canlet.2005.06.048

L. Tallec, B. Dutrillaux, B. Lachages, A. M. Millot, G. A. Brison et al., Molecular profiling of common fragile sites in human fibroblasts, Nature Structural & Molecular Biology, vol.75, issue.12, pp.1421-1423, 2011.
DOI : 10.1101/sqb.2010.75.011

A. Letessier, G. A. Millot, S. Koundrioukoff, A. M. Lachagè-s, N. Vogt et al., Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site, Nature, vol.45, issue.7332, pp.120-123, 2011.
DOI : 10.2144/000113002

S. Mcavoy, S. C. Ganapathiraju, A. L. Ducharme-smith, J. R. Pritchett, F. Kosari et al., Non-random inactivation of large common fragile site genes in different cancers, Cytogenetic and Genome Research, vol.118, issue.2-4, pp.260-269, 2007.
DOI : 10.1159/000108309

M. Mé-chali, Eukaryotic DNA replication origins: many choices for appropriate answers, Nature Reviews Molecular Cell Biology, vol.21, issue.10, pp.728-738, 2010.
DOI : 10.4161/cc.8.3.7649

K. Mrasek, C. Schoder, A. C. Teichmann, K. Behr, B. Franze et al., Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones, Int. J. Oncol, vol.36, pp.929-940, 2010.

I. Murano, A. Kuwano, and T. Kajii, Fibroblast-specific common fragile sites induced by aphidicolin, Human Genetics, vol.1, issue.1, pp.45-48, 1989.
DOI : 10.1007/BF00274145

T. Ryba, I. Hiratani, J. Lu, M. Itoh, M. Kulik et al., Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types, Genome Research, vol.20, issue.6, pp.761-770, 2010.
DOI : 10.1101/gr.099655.109
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877573

J. C. Saldivar, S. Miuma, J. Bene, S. A. Hosseini, H. Shibata et al., Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression, PLoS Genetics, vol.554, issue.11, 2012.
DOI : 10.1371/journal.pgen.1003077.s008

T. Schepeler, P. Lamy, J. R. Laurberg, N. Fristrup, T. Reinert et al., A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response, Oncogene, vol.29, issue.31, 2012.
DOI : 10.1038/nbt.1754

D. I. Smith, S. Mcavoy, Y. Zhu, and D. S. Perez, Large common fragile site genes and cancer, Seminars in Cancer Biology, vol.17, issue.1, pp.31-41, 2007.
DOI : 10.1016/j.semcancer.2006.10.003

N. L. Solimini, Q. Xu, C. H. Mermel, A. C. Liang, M. R. Schlabach et al., Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential, Science, vol.169, issue.4, pp.104-109, 2012.
DOI : 10.1534/genetics.104.036871
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027969