Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG?

Abstract : Five years ago, we reported the identification and characterization of several regulatory T-cell epitopes (now called Tregitopes) that were discovered in the heavy and light chains of IgG (De Groot et al. Blood, 2008). When added ex vivo to human PBMCs, these Tregitopes activated regulatory T cells (Tregs), increased expression of the transcription factor FoxP3, and induced IL-10 expression in CD4 + T cells. We have now shown that coadministration of the Tregitopes in vivo, in a number of different murine models of autoimmune disease, can suppress immune responses to antigen in an antigen-specific manner, and that this response is mediated by Tregs. In addition we have shown that, although these are generally promiscuous epitopes, the activity of individual Tregitope peptides is restricted by HLA. In this brief report, we provide an overview of the effects of Tregitopes in vivo, discuss potential applications, and suggest that Tregitopes may represent one of the " active pharmaceutical ingredients " of IVIg. Tregitope applications may include any of the autoimmune diseases that are currently treated almost exclusively with intravenous immunoglobulin G (IVIG), such as Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Multifocal Motor Neuropathy (MMN), as well as gene therapy and allergy where Tregitopes may provide a means of inducing antigen-specific tolerance.
Type de document :
Article dans une revue
Clinical and Developmental Immunology, Hindawi Publishing Corporation, 2013, 2013, pp.493138. 〈10.1155/2013/493138〉
Liste complète des métadonnées

Littérature citée [59 références]  Voir  Masquer  Télécharger

http://hal.upmc.fr/hal-01548800
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : mercredi 28 juin 2017 - 10:15:16
Dernière modification le : jeudi 29 juin 2017 - 17:52:05
Document(s) archivé(s) le : mercredi 17 janvier 2018 - 22:28:29

Fichier

493138.pdf
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Anne S. De Groot, Leslie Cousens, Federico Mingozzi, William Martin. Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG?. Clinical and Developmental Immunology, Hindawi Publishing Corporation, 2013, 2013, pp.493138. 〈10.1155/2013/493138〉. 〈hal-01548800〉

Partager

Métriques

Consultations de la notice

16

Téléchargements de fichiers

25