. French and . Law, Journal officiel, pp.1245-1247, 2004.

C. A. Borgono and E. P. Diamandis, The emerging roles of human tissue kallikreins in cancer, Nature Reviews Cancer, vol.169, issue.11, pp.876-890, 2004.
DOI : 10.1016/S0022-5347(05)64127-4

C. Caubet, N. Jonca, M. Brattsand, M. Guerrin, D. Bernard et al., Degradation of Corneodesmosome Proteins by Two Serine Proteases of the Kallikrein Family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7, Journal of Investigative Dermatology, vol.122, issue.5, pp.1235-1244, 2004.
DOI : 10.1111/j.0022-202X.2004.22512.x

H. Chung, M. Hamza, K. Oikonomopoulou, V. Gratio, M. Saifeddine et al., Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors, Biological Chemistry, vol.24, issue.5, pp.413-420, 2012.
DOI : 10.1016/0092-8674(91)90261-V

D. Darmoul, V. Gratio, H. Devaud, T. Lehy, and M. Laburthe, Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells, The American Journal of Pathology, vol.162, issue.5, pp.1503-1513, 2003.
DOI : 10.1016/S0002-9440(10)64283-6

D. Darmoul, V. Gratio, H. Devaud, F. Peiretti, and M. Laburthe, Activation of proteinaseactivated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation, Mol Cancer Res, vol.2, issue.9, pp.514-522, 2004.

D. Darmoul, J. C. Marie, H. Devaud, V. Gratio, and M. Laburthe, Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2, British Journal of Cancer, vol.272, issue.5, pp.772-779, 2001.
DOI : 10.1054/bjoc.2001.1976

M. Devetzi, T. Trangas, A. Scorilas, D. Xynopoulos, and M. Talieri, Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and, p.14, 2013.

Y. Dong, D. Loessner, H. Irving-rodgers, A. Obermair, J. L. Nicklin et al., Metastasis of ovarian cancer is mediated by kallikrein related peptidases, Clinical & Experimental Metastasis, vol.33, issue.1, pp.135-147, 2014.
DOI : 10.1016/j.tips.2012.09.005

Y. Dong, N. Matigian, T. J. Harvey, H. Samaratunga, J. D. Hooper et al., Tissuespecific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function, Biol Chem, vol.389, issue.2, pp.99-109, 2008.

Y. Dong, O. L. Tan, D. Loessner, C. Stephens, C. Walpole et al., Kallikrein-Related Peptidase 7 Promotes Multicellular Aggregation via the ?5?1 Integrin Pathway and Paclitaxel Chemoresistance in Serous Epithelial Ovarian Carcinoma, Cancer Research, vol.70, issue.7, pp.2624-2633, 2010.
DOI : 10.1158/0008-5472.CAN-09-3415

J. Dorn, A. Gkazepis, M. Kotzsch, M. Kremer, C. Propping et al., Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer, Biological Chemistry, vol.395, issue.1, pp.95-107, 2014.
DOI : 10.1515/hsz-2013-0172

N. Dumaz, R. Hayward, J. Martin, L. Ogilvie, D. Hedley et al., In Melanoma, RAS Mutations Are Accompanied by Switching Signaling from BRAF to CRAF and Disrupted Cyclic AMP Signaling, Cancer Research, vol.66, issue.19, pp.9483-9491, 2006.
DOI : 10.1158/0008-5472.CAN-05-4227

T. Egelrud, M. Brattsand, P. Kreutzmann, M. Walden, K. Vitzithum et al., hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6, British Journal of Dermatology, vol.5, issue.6, pp.1200-1203, 2005.
DOI : 10.1101/gad.1232104

N. Emami and E. P. Diamandis, Human tissue kallikreins: A road under construction, Clinica Chimica Acta, vol.381, issue.1, pp.78-84, 2007.
DOI : 10.1016/j.cca.2007.02.023

P. S. Filippou, G. S. Karagiannis, N. Musrap, and E. P. Diamandis, Kallikrein-related peptidases (KLKs) and the hallmarks of cancer, Critical Reviews in Clinical Laboratory Sciences, vol.68, issue.4, pp.277-291, 2015.
DOI : 10.1515/hsz-2014-0129

J. Fischer and U. Meyer-hoffert, Regulation of kallikrein-related peptidases in the skin ??? from physiology to diseases to therapeutic options, Thrombosis and Haemostasis, vol.110, issue.3, pp.442-449, 2013.
DOI : 10.1160/TH12-11-0836

K. T. Flaherty, F. S. Hodi, and D. E. Fisher, From genes to drugs: targeted strategies for melanoma, Nature Reviews Cancer, vol.3, issue.5, pp.349-361, 2012.
DOI : 10.1038/ncomms1727

E. Frohlich, Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target, Cellular and Molecular Life Sciences, vol.47, issue.Suppl 6, pp.3947-3960, 2010.
DOI : 10.1016/S0344-0338(99)80030-2

M. Gabril, N. M. White, M. Moussa, T. F. Chow, S. M. Metias et al., Immunohistochemical analysis of kallikrein-related peptidases in the normal kidney and renal tumors: potential clinical implications, Biological Chemistry, vol.46, issue.4, pp.403-409, 2010.
DOI : 10.1016/S0065-2423(04)39002-5

V. Gratio, N. Beaufort, L. Seiz, J. Maier, G. D. Virca et al., Kallikrein-Related Peptidase 4, The American Journal of Pathology, vol.176, issue.3, pp.1452-1461, 2010.
DOI : 10.2353/ajpath.2010.090523
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832164

V. Gratio, C. Loriot, G. D. Virca, K. Oikonomopoulou, F. Walker et al., Kallikrein-Related Peptidase 14 Acts on Proteinase-Activated Receptor 2 to Induce Signaling Pathway in Colon Cancer Cells, The American Journal of Pathology, vol.179, issue.5, pp.2625-2636, 2011.
DOI : 10.1016/j.ajpath.2011.07.016

N. K. Haass and M. Herlyn, Normal Human Melanocyte Homeostasis as a Paradigm for Understanding Melanoma, Journal of Investigative Dermatology Symposium Proceedings, vol.10, issue.2, pp.153-163, 2005.
DOI : 10.1111/j.1087-0024.2005.200407.x
URL : http://doi.org/10.1111/j.1087-0024.2005.200407.x

Y. Hatano, Y. Adachi, P. M. Elias, D. Crumrine, T. Sakai et al., The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis, Experimental Dermatology, vol.43, issue.1, pp.30-35, 2013.
DOI : 10.1016/j.jdermsci.2006.06.003

K. S. Hoek, O. M. Eichhoff, N. C. Schlegel, U. Dobbeling, N. Kobert et al., In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States, Cancer Research, vol.68, issue.3, pp.650-656, 2008.
DOI : 10.1158/0008-5472.CAN-07-2491

V. Iakovlev, E. Siegel, M. Tsao, and R. Haun, Expression of Kallikrein-Related Peptidase 7 Predicts Poor Prognosis in Patients with Unresectable Pancreatic Ductal Adenocarcinoma, Cancer Epidemiology Biomarkers & Prevention, vol.21, issue.7, 2012.
DOI : 10.1158/1055-9965.EPI-11-1079

S. K. Johnson, V. C. Ramani, L. Hennings, and R. S. Haun, Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin, Cancer, vol.62, issue.9, pp.1811-1820, 2007.
DOI : 10.1177/42.4.7510318

M. Kalinska, U. Meyer-hoffert, T. Kantyka, and J. Potempa, Kallikreins ? The melting pot of activity and function, Biochimie, vol.122, pp.270-282, 2016.
DOI : 10.1016/j.biochi.2015.09.023

H. S. Kim, D. H. Kim, J. Y. Kim, N. H. Jeoung, I. K. Lee et al., Microarray Analysis of Papillary Thyroid Cancers in Korean, The Korean Journal of Internal Medicine, vol.25, issue.4, pp.399-407, 2010.
DOI : 10.3904/kjim.2010.25.4.399

J. E. Kim, E. Leung, B. C. Baguley, and G. J. Finlay, Heterogeneity of expression of epithelialmesenchymal transition markers in melanocytes and melanoma cell lines, Front Genet, vol.4, p.97, 2013.

S. Krenzer, H. Peterziel, C. Mauch, S. I. Blaber, M. Blaber et al., Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment, Journal of Investigative Dermatology, vol.131, issue.11, pp.2281-2288, 2011.
DOI : 10.1038/jid.2011.190

T. Kryza, M. L. Silva, D. Loessner, N. Heuze-vourc-'h, and J. A. Clements, The kallikrein-related peptidase family: Dysregulation and functions during cancer progression, Biochimie, vol.122, pp.283-299, 2016.
DOI : 10.1016/j.biochi.2015.09.002

A. Lundwall and M. Brattsand, Kallikrein-related peptidases, Cellular and Molecular Life Sciences, vol.65, issue.13, pp.2019-2038, 2008.
DOI : 10.1007/s00018-008-8024-3

W. K. Martins, G. H. Esteves, O. M. Almeida, G. G. Rezze, G. Landman et al., Gene network analyses point to the importance of human tissue kallikreins in melanoma progression, BMC Medical Genomics, vol.286, issue.1, p.76, 2011.
DOI : 10.1074/jbc.M110.125310

L. Mo, J. Zhang, J. Shi, Q. Xuan, X. Yang et al., Human kallikrein 7 induces epithelial-mesenchymal transition-like changes in prostate carcinoma cells: a role in prostate cancer invasion and progression, Anticancer Res, vol.30, issue.9, pp.3413-3420, 2010.

M. E. Neville, K. M. Pezzella, and J. J. Huang, In vivo inhibition of tumor growth of B16 melanoma by recombinant interleukin 1??, Cytokine, vol.2, issue.6, pp.456-463, 1990.
DOI : 10.1016/1043-4666(90)90055-X

E. Nylander-lundqvist and T. Egelrud, Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro, Acta Derm Venereol, vol.77, issue.3, pp.203-206, 1997.

R. L. Pearlman, M. K. Montes-de-oca, H. C. Pal, and F. Afaq, Potential therapeutic targets of epithelial?mesenchymal transition in melanoma, Cancer Letters, vol.391, pp.125-140, 2017.
DOI : 10.1016/j.canlet.2017.01.029

D. Pepin, Z. Q. Shao, G. Huppe, A. Wakefield, C. W. Chu et al., Kallikreins 5, 6 and 10 Differentially Alter Pathophysiology and Overall Survival in an Ovarian Cancer Xenograft Model, PLoS ONE, vol.4, issue.11, p.26075, 2011.
DOI : 10.1371/journal.pone.0026075.s002

L. M. Postovit, E. A. Seftor, R. E. Seftor, and M. J. Hendrix, Influence of the Microenvironment on Melanoma Cell Fate Determination and Phenotype, Cancer Research, vol.66, issue.16, pp.7833-7836, 2006.
DOI : 10.1158/0008-5472.CAN-06-0731

P. Prezas, M. J. Arlt, P. Viktorov, A. Soosaipillai, L. Holzscheiter et al., Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells, Biological Chemistry, vol.63, issue.6, pp.807-811, 2006.
DOI : 10.1038/sj.bjc.6601451

Z. Rakosy, S. Ecsedi, R. Toth, L. Vizkeleti, H. Hernandez-vargas et al., Integrative Genomics Identifies Gene Signature Associated with Melanoma Ulceration, PLoS ONE, vol.5, issue.1, p.54958, 2013.
DOI : 10.1371/journal.pone.0054958.s007
URL : http://doi.org/10.1371/journal.pone.0054958

V. C. Ramani and R. S. Haun, Expression of Kallikrein 7 Diminishes Pancreatic Cancer Cell Adhesion to Vitronectin and Enhances Urokinase-Type Plasminogen Activator Receptor Shedding, Pancreas, vol.37, issue.4, pp.399-404, 2008.
DOI : 10.1097/MPA.0b013e31817f76f7

V. C. Ramani, L. Hennings, and R. S. Haun, Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer, BMC Cancer, vol.171, issue.3, p.373, 2008.
DOI : 10.2353/ajpath.2007.070028

V. C. Ramani, G. P. Kaushal, and R. S. Haun, Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1813, issue.8, pp.1813-1525, 2011.
DOI : 10.1016/j.bbamcr.2011.05.007

A. J. Ramsay, J. C. Reid, M. N. Adams, H. Samaratunga, Y. Dong et al., Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs), Biological Chemistry, vol.11, issue.6, pp.653-668, 2008.
DOI : 10.1373/clinchem.2005.049692

G. G. Rezze, J. H. Fregnani, J. Duprat, and G. Landman, Cell adhesion and communication proteins are differentially expressed in melanoma progression model????, Human Pathology, vol.42, issue.3, pp.409-418, 2011.
DOI : 10.1016/j.humpath.2010.09.004

L. Sevenich, J. , and J. A. , Pericellular proteolysis in cancer, Genes & Development, vol.28, issue.21, pp.2331-2347, 2014.
DOI : 10.1101/gad.250647.114
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215179

J. L. Shaw and E. P. Diamandis, Distribution of 15 Human Kallikreins in Tissues and Biological Fluids, Clinical Chemistry, vol.53, issue.8, pp.1423-1432, 2007.
DOI : 10.1373/clinchem.2007.088104

G. Sotiropoulou, G. Pampalakis, and E. P. Diamandis, Functional Roles of Human Kallikrein-related Peptidases, Journal of Biological Chemistry, vol.58, issue.48, pp.32989-32994, 2009.
DOI : 10.1016/j.chembiol.2009.05.008
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785139

A. C. Stefanini, B. R. Da-cunha, T. Henrique, and E. H. Tajara, Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. Dis Markers, p.946572, 2015.

K. Stefansson, M. Brattsand, D. Roosterman, C. Kempkes, G. Bocheva et al., Activation of Proteinase-Activated Receptor-2 by Human Kallikrein-Related Peptidases, Journal of Investigative Dermatology, vol.128, issue.1, pp.18-25, 2008.
DOI : 10.1038/sj.jid.5700965

T. L. Veveris-lowe, M. G. Lawrence, R. L. Collard, L. Bui, A. C. Herington et al., Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells, Endocrine Related Cancer, vol.12, issue.3, pp.631-643, 2005.
DOI : 10.1677/erc.1.00958

F. Walker, P. Nicole, A. Jallane, A. Soosaipillai, V. Mosbach et al., Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer, Biological Chemistry, vol.395, issue.9, pp.1075-1086, 2014.
DOI : 10.1515/hsz-2014-0142

V. Winnepenninckx, V. Lazar, S. Michiels, P. Dessen, M. Stas et al., Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome, JNCI Journal of the National Cancer Institute, vol.98, issue.7, pp.98-472, 2006.
DOI : 10.1093/jnci/djj103

S. Xi, S. Inchauste, H. Guo, J. Shan, Z. Xiao et al., Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis, Oncogene, vol.5, issue.44, pp.34-5548, 2015.
DOI : 10.1371/journal.pone.0013764

X. Yang, Q. Xuan, L. Mo, F. Huang, Y. Pang et al., Differential expression of genes in co-cultured versus separately cultured fibroblasts and epithelial cells from human benign hyperplastic prostate tissues, Int J Mol Med, vol.26, issue.1, pp.17-25, 2010.

G. M. Yousef, M. E. Polymeris, G. M. Yacoub, A. Scorilas, A. Soosaipillai et al., Parallel overexpression of seven kallikrein genes in ovarian cancer, Cancer Res, vol.63, issue.9, pp.2223-2227, 2003.

G. M. Yousef, A. Scorilas, A. Magklara, A. Soosaipillai, and E. P. Diamandis, The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family ??? genomic characterization, mapping, tissue expression and hormonal regulation, Gene, vol.254, issue.1-2, pp.119-128, 2000.
DOI : 10.1016/S0378-1119(00)00280-8