Self-Referential Processing, Rumination, and Cortical Midline Structures in Major Depression

Abstract : Major depression is associated with a bias toward negative emotional processing and increased self-focus, i.e., the process by which one engages in self-referential processing. The increased self-focus in depression is suggested to be of a persistent, repetitive and self-critical nature, and is conceptualized as ruminative brooding. The role of the medial prefrontal cortex in self-referential processing has been previously emphasized in acute major depression. There is increasing evidence that self-referential processing as well as the cortical midline structures play a major role in the development, course, and treatment response of major depressive disorder. However, the links between self-referential processing, rumination, and the cortical midline structures in depression are still poorly understood. Here, we reviewed brain imaging studies in depressed patients and healthy subjects that have examined these links. Self-referential processing in major depression seems associated with abnormally increased activity of the anterior cortical midline structures. Abnormal interactions between the lateralized task-positive network, and the midline cortical structures of the default mode network, as well as the emotional response network , may underlie the pervasiveness of ruminative brooding. Furthermore, targeting this maladaptive form of rumination and its underlying neural correlates may be key for effective treatment.
Type de document :
Article dans une revue
Frontiers in Human Neuroscience, Frontiers, 2013, 7, pp.666. 〈10.3389/fnhum.2013.00666〉
Liste complète des métadonnées

Littérature citée [77 références]  Voir  Masquer  Télécharger

http://hal.upmc.fr/hal-01557431
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : jeudi 6 juillet 2017 - 11:27:35
Dernière modification le : jeudi 11 janvier 2018 - 06:25:43
Document(s) archivé(s) le : mardi 23 janvier 2018 - 22:54:44

Fichier

fnhum-07-00666.pdf
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Ayna Baladi Nejad, Philippe Fossati, Cédric Lemogne. Self-Referential Processing, Rumination, and Cortical Midline Structures in Major Depression. Frontiers in Human Neuroscience, Frontiers, 2013, 7, pp.666. 〈10.3389/fnhum.2013.00666〉. 〈hal-01557431〉

Partager

Métriques

Consultations de la notice

69

Téléchargements de fichiers

35