Contribution of the supplementary motor area and the cerebellum to the anticipatory postural adjustments and execution phases of human gait initiation

Abstract : Several brain structures including the brainstem, the cerebellum and the frontal cortico-basal ganglia network, with the primary and premotor areas have been shown to participate in the functional organization of gait initiation and postural control in humans, but their respective roles remain poorly understood. The aim of this study was to better understand the role of the supplementary motor area (SMA) and posterior cerebellum in the gait initiation process. Gait initiation parameters were recorded in 22 controls both before and after continuous theta burst transcranial stimulation (cTBS) of the SMA and cerebellum, and were compared to sham stimulation, using a randomized double-blind design study. The two phases of gait initiation process were analyzed: anticipatory postural adjustments (APAs) and execution, with recordings of soleus and tibialis anterior muscles. Functional inhibition of the SMA led to a shortened APA phase duration with advanced and increased muscle activity; during execution, it also advanced muscle co-activation and decreased the duration of stance soleus activity. Cerebellar functional inhibition did not influence the APA phase duration and amplitude but increased muscle co-activation, it decreased execution duration and showed a trend to increase velocity, with increased swing soleus muscle duration and activity. The results suggest that the SMA contributes to both the timing and amplitude of the APAs with no influence on step execution and the posterior cerebellum in the coupling between the APAs and execution phases and leg muscle activity pattern during gait initiation.
Type de document :
Article dans une revue
Neuroscience, Elsevier - International Brain Research Organization, 2017, 〈10.1016/j.neuroscience.2017.06.047〉
Liste complète des métadonnées

Littérature citée [69 références]  Voir  Masquer  Télécharger

http://hal.upmc.fr/hal-01558251
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : mardi 11 juillet 2017 - 12:00:57
Dernière modification le : mercredi 21 mars 2018 - 18:57:51
Document(s) archivé(s) le : jeudi 25 janvier 2018 - 03:31:24

Fichier

Richard_Contribution_of_the.pd...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

ICM | UPMC

Citation

Aliénor Richard, Angèle Van Hamme, Xavier Drevelle, Jean-Louis Golmard, Sabine Meunier, et al.. Contribution of the supplementary motor area and the cerebellum to the anticipatory postural adjustments and execution phases of human gait initiation. Neuroscience, Elsevier - International Brain Research Organization, 2017, 〈10.1016/j.neuroscience.2017.06.047〉. 〈hal-01558251〉

Partager

Métriques

Consultations de la notice

80

Téléchargements de fichiers

18