The Role of Cyclic 3’-5’ Adenosine Monophosphate (cAMP) in Differentiated and Trans-Differentiated Vascular Smooth Muscle Cells - Sorbonne Université Accéder directement au contenu
Chapitre D'ouvrage Année : 2013

The Role of Cyclic 3’-5’ Adenosine Monophosphate (cAMP) in Differentiated and Trans-Differentiated Vascular Smooth Muscle Cells

Résumé

Vascular Smooth Muscle Cells (VSMC) are highly specialized cells whose principal functions are contraction and regulation of blood vessel tone-diameter, blood pressure, and blood flow distribution. In healthy adult blood vessels, these cells proliferate at a very low rate, exhibit very low synthetic and migratory activity and express a unique repertoire of contractile proteins, ion channels, and signalling molecules required for the cell's contractile function. VSMC undergo significant phenotypic modulation following vascular injuries including hypoxia, oxidative stress and mechanical injury. This phenotypic transition is mainly characterized by the loss of contractility and the acquisition of a proliferative, migratory and synthetic phenotype.

Dates et versions

hal-01563301 , version 1 (17-07-2017)

Identifiants

Citer

Martine Glorian, Isabelle Limon. The Role of Cyclic 3’-5’ Adenosine Monophosphate (cAMP) in Differentiated and Trans-Differentiated Vascular Smooth Muscle Cells. Rita Rezzani. Current Trends in Atherogenesis, InTech, 2013, 978-953-51-1011-8. ⟨10.5772/54726⟩. ⟨hal-01563301⟩
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