The Role of Cyclic 3’-5’ Adenosine Monophosphate (cAMP) in Differentiated and Trans-Differentiated Vascular Smooth Muscle Cells

Martine Glorian 1 Isabelle Limon 1
1 CPCML - Contrôle du Phénotype des Cellules Musculaires Lisses
B2A - Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing
Abstract : Vascular Smooth Muscle Cells (VSMC) are highly specialized cells whose principal functions are contraction and regulation of blood vessel tone-diameter, blood pressure, and blood flow distribution. In healthy adult blood vessels, these cells proliferate at a very low rate, exhibit very low synthetic and migratory activity and express a unique repertoire of contractile proteins, ion channels, and signalling molecules required for the cell's contractile function. VSMC undergo significant phenotypic modulation following vascular injuries including hypoxia, oxidative stress and mechanical injury. This phenotypic transition is mainly characterized by the loss of contractility and the acquisition of a proliferative, migratory and synthetic phenotype.
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Chapitre d'ouvrage
Rita Rezzani. Current Trends in Atherogenesis, InTech, 2013, 978-953-51-1011-8. 〈10.5772/54726 〉
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Soumis le : lundi 17 juillet 2017 - 15:35:03
Dernière modification le : jeudi 11 janvier 2018 - 06:28:10

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Martine Glorian, Isabelle Limon. The Role of Cyclic 3’-5’ Adenosine Monophosphate (cAMP) in Differentiated and Trans-Differentiated Vascular Smooth Muscle Cells. Rita Rezzani. Current Trends in Atherogenesis, InTech, 2013, 978-953-51-1011-8. 〈10.5772/54726 〉. 〈hal-01563301〉

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