From cells to tissue: A continuum model of epithelial mechanics

Abstract : A two-dimensional continuum model of epithelial tissue mechanics was formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model incorporates stress and deformation tensors, which can be compared with experimental data. Focusing on the interplay between cell shape changes and cell rearrangements, we elucidated dynamical behavior underlying passive relaxation, active contraction-elongation, and tissue shear flow, including a mechanism for contraction-elongation, whereby tissue flows perpendicularly to the axis of cell elongation. This study provides an integrated scheme for the understanding of the orchestration of morphogenetic processes in individual cells to achieve epithelial tissue morphogenesis.
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Physical Review E , American Physical Society (APS), 2017, 96 (2), 〈10.1103/PhysRevE.96.022418〉
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http://hal.upmc.fr/hal-01580627
Contributeur : Philippe Marcq <>
Soumis le : vendredi 1 septembre 2017 - 19:01:08
Dernière modification le : mercredi 21 mars 2018 - 18:57:05

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Shuji Ishihara, Philippe Marcq, Kaoru Sugimura. From cells to tissue: A continuum model of epithelial mechanics. Physical Review E , American Physical Society (APS), 2017, 96 (2), 〈10.1103/PhysRevE.96.022418〉. 〈hal-01580627〉

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