C. Chapat and L. Corbo, Novel roles of the CCR4-NOT complex, Wiley Interdisciplinary Reviews: RNA, vol.77, issue.6, pp.883-901, 2014.
DOI : 10.1016/S0079-6603(04)77008-7
URL : https://hal.archives-ouvertes.fr/tel-01169332

M. A. Collart and O. O. Panasenko, The Ccr4???Not complex, Gene, vol.492, issue.1, pp.42-53, 2012.
DOI : 10.1016/j.gene.2011.09.033

E. Wahle and G. S. Winkler, RNA decay machines: Deadenylation by the Ccr4???Not and Pan2???Pan3 complexes, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, vol.1829, issue.6-7, pp.1829-561, 2013.
DOI : 10.1016/j.bbagrm.2013.01.003

A. C. Goldstrohm and M. Wickens, Multifunctional deadenylase complexes diversify mRNA control, Nature Reviews Molecular Cell Biology, vol.18, issue.4, pp.337-344, 2008.
DOI : 10.1093/emboj/21.6.1427

F. Mauxion, B. Preve, and B. Seraphin, C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex, RNA Biology, vol.118, issue.2, pp.267-276, 2013.
DOI : 10.1074/jbc.M604986200

Y. Chen, A. Boland, D. Kuzuoglu-ozturk, P. Bawankar, B. Loh et al., A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing, Molecular Cell, vol.54, issue.5, pp.737-750, 2014.
DOI : 10.1016/j.molcel.2014.03.034

A. Boland, Y. Chen, T. Raisch, S. Jonas, D. Kuzuoglu-ozturk et al., Structure and assembly of the NOT module of the human CCR4???NOT complex, Nature Structural & Molecular Biology, vol.277, issue.11, pp.1289-1297, 2013.
DOI : 10.1038/sj.emboj.7601588

M. Morita, T. Suzuki, T. Nakamura, K. Yokoyama, T. Miyasaka et al., Depletion of Mammalian CCR4b Deadenylase Triggers Elevation of the p27Kip1 mRNA Level and Impairs Cell Growth, Molecular and Cellular Biology, vol.27, issue.13, pp.4980-4990, 2007.
DOI : 10.1128/MCB.02304-06

A. Dupressoir, A. P. Morel, W. Barbot, M. P. Loireau, L. Corbo et al., Identification of four families of yCCR4-and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding, BMC Genomics, vol.2, issue.1, p.9, 2001.
DOI : 10.1186/1471-2164-2-9

C. Bianchin, F. Mauxion, S. Sentis, B. Seraphin, and L. Corbo, Conservation of the deadenylase activity of proteins of the Caf1 family in human, RNA, vol.11, issue.4, pp.487-494, 2005.
DOI : 10.1261/rna.7135305

M. C. Daugeron, F. Mauxion, and B. Seraphin, The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation, Nucleic Acids Research, vol.29, issue.12, pp.2448-2455, 2001.
DOI : 10.1093/nar/29.12.2448

H. Mathys, J. Basquin, S. Ozgur, M. Czarnocki-cieciura, F. Bonneau et al., Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression, Molecular Cell, vol.54, issue.5, pp.751-765, 2014.
DOI : 10.1016/j.molcel.2014.03.036

T. Nishimura, Z. Padamsi, H. Fakim, S. Milette, W. H. Dunham et al., The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5??? and 3??? Termini of Target mRNAs, Cell Reports, vol.11, issue.9, pp.1425-1436, 2015.
DOI : 10.1016/j.celrep.2015.04.065

S. Ozgur, J. Basquin, A. Kamenska, W. Filipowicz, N. Standart et al., Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex, Cell Reports, vol.13, issue.4, pp.703-711, 2015.
DOI : 10.1016/j.celrep.2015.09.033

S. Waghray, C. Williams, J. J. Coon, and M. Wickens, CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo, RNA, vol.21, issue.7, pp.1335-1345, 2015.
DOI : 10.1261/rna.051565.115

C. Chapat, S. M. Jafarnejad, E. Matta-camacho, G. G. Hesketh, I. A. Gelbart et al., Cap-binding protein 4EHP effects translation silencing by microRNAs, Proceedings of the National Academy of Sciences, vol.149, issue.21, pp.5425-5430, 2017.
DOI : 10.1093/nar/gkv720

A. Eulalio, I. Behm-ansmant, D. Schweizer, and E. Izaurralde, P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing, Molecular and Cellular Biology, vol.27, issue.11, pp.3970-3981, 2007.
DOI : 10.1128/MCB.00128-07

D. Zheng, N. Ezzeddine, C. Y. Chen, W. Zhu, X. He et al., Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells, The Journal of Cell Biology, vol.14, issue.1, pp.89-101, 2008.
DOI : 10.1261/rna.411907

J. C. Reese, The control of elongation by the yeast Ccr4???Not complex, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, vol.1829, issue.1, pp.1829-127, 2013.
DOI : 10.1016/j.bbagrm.2012.09.001

V. Badarinarayana, Y. C. Chiang, and C. L. Denis, Functional interaction of CCR4?NOT proteins with TATAA-binding protein (TBP) and its associated factors in yeast, Genetics, vol.155, pp.1045-1054, 2000.

C. Deluen, N. James, L. Maillet, M. Molinete, G. Theiler et al., The Ccr4-Not Complex and yTAF1 (yTafII130p/yTafII145p) Show Physical and Functional Interactions, Molecular and Cellular Biology, vol.22, issue.19, pp.6735-6749, 2002.
DOI : 10.1128/MCB.22.19.6735-6749.2002
URL : http://mcb.asm.org/content/22/19/6735.full.pdf

C. Chapat, C. Kolytcheff, L. Romancer, M. Auboeuf, D. De-la-grange et al., hCAF1/CNOT7 regulates interferon signalling by targeting STAT1, The EMBO Journal, vol.148, issue.5, pp.688-700, 2013.
DOI : 10.1083/jcb.200801196
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594750

G. S. Winkler, K. W. Mulder, V. J. Bardwell, E. Kalkhoven, and H. T. Timmers, Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription, The EMBO Journal, vol.92, issue.13, pp.3089-3099, 2006.
DOI : 10.1074/jbc.M311747200

D. Prevot, A. P. Morel, T. Voeltzel, M. C. Rostan, R. Rimokh et al., Relationships of the Antiproliferative Proteins BTG1 and BTG2 with CAF1, the Human Homolog of a Component of the Yeast CCR4 Transcriptional Complex, Journal of Biological Chemistry, vol.19, issue.13, pp.9640-9648, 2001.
DOI : 10.1016/S0092-8674(00)81879-6

N. C. Lau, A. Kolkman, F. M. Van-schaik, K. W. Mulder, W. W. Pijnappel et al., Human Ccr4???Not complexes contain variable deadenylase subunits, Biochemical Journal, vol.6, issue.3, pp.443-453, 2009.
DOI : 10.1261/rna.7135305
URL : https://hal.archives-ouvertes.fr/hal-00479183

Y. Robin-lespinasse, S. Sentis, C. Kolytcheff, M. C. Rostan, L. Corbo et al., hCAF1, a new regulator of PRMT1-dependent arginine methylation, Journal of Cell Science, vol.120, issue.4, pp.638-647, 2007.
DOI : 10.1242/jcs.03357

S. C. Kerr, N. Azzouz, S. M. Fuchs, M. A. Collart, B. D. Strahl et al., The Ccr4-Not Complex Interacts with the mRNA Export Machinery, PLoS ONE, vol.122, issue.3, p.18302, 2011.
DOI : 10.1371/journal.pone.0018302.s002

A. P. Morel, S. Sentis, C. Bianchin, L. Romancer, M. Jonard et al., BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms, Journal of Cell Science, vol.116, issue.14, pp.2929-2936, 2003.
DOI : 10.1242/jcs.00480

R. Elkon, A. P. Ugalde, and R. Agami, Alternative cleavage and polyadenylation: extent, regulation and function, Nature Reviews Genetics, vol.73, issue.7, pp.496-506, 2013.
DOI : 10.1086/376608

D. Giammartino, D. C. Nishida, K. Manley, and J. L. , Mechanisms and Consequences of Alternative Polyadenylation, Molecular Cell, vol.43, issue.6, pp.853-866, 2011.
DOI : 10.1016/j.molcel.2011.08.017

J. P. Rouault, D. Prevot, C. Berthet, A. M. Birot, M. Billaud et al., Gene Products with mCaf1, the Murine Homolog of a Component of the Yeast CCR4 Transcriptional Regulatory Complex, Journal of Biological Chemistry, vol.140, issue.35, pp.22563-22569, 1998.
DOI : 10.1093/nar/25.24.5110

J. I. Garrels, [28] Quantitative two-dimensional gel electrophoresis of proteins, Methods Enzymol, vol.100, pp.411-423, 1983.
DOI : 10.1016/0076-6879(83)00070-1

Y. Xu, X. D. Gao, J. H. Lee, H. Huang, H. Tan et al., Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing, Genes & Development, vol.28, issue.11, pp.1191-1203, 2014.
DOI : 10.1101/gad.241968.114

P. De-la-grange, M. Dutertre, . Martin, and D. Auboeuf, FAST DB: a website resource for the study of the expression regulation of human gene products, Nucleic Acids Research, vol.33, issue.13, pp.4276-4284, 2005.
DOI : 10.1093/nar/gki738

P. De-la-grange, M. Dutertre, M. Correa, and D. Auboeuf, A new advance in alternative splicing databases: from catalogue to detailed analysis of regulation of expression and function of human alternative splicing variants, BMC Bioinformatics, vol.8, issue.1, p.180, 2007.
DOI : 10.1186/1471-2105-8-180

E. Wang, V. Aslanzadeh, F. Papa, H. Zhu, P. De-la-grange et al., Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F, PLoS ONE, vol.60, issue.12, p.51266, 2012.
DOI : 10.1371/journal.pone.0051266.s006

S. Gandoura, E. Weiss, P. E. Rautou, M. Fasseu, T. Gustot et al., Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis, Journal of Hepatology, vol.58, issue.5, pp.936-948, 2013.
DOI : 10.1016/j.jhep.2012.12.025

C. Colombrita, E. Onesto, E. Buratti, P. De-la-grange, V. Gumina et al., From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, vol.1849, issue.12, pp.1849-1398, 2015.
DOI : 10.1016/j.bbagrm.2015.10.015

J. A. Bogdan, C. Adams-burton, D. L. Pedicord, D. A. Sukovich, P. A. Benfield et al., Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1, Biochemical Journal, vol.336, issue.2, pp.471-481, 1998.
DOI : 10.1042/bj3360471

M. Biasini, S. Bienert, A. Waterhouse, K. Arnold, G. Studer et al., SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information, Nucleic Acids Research, vol.42, issue.W1, pp.252-258, 2014.
DOI : 10.1093/nar/gku340

A. Aslam, S. Mittal, F. Koch, J. C. Andrau, and G. S. Winkler, The Ccr4-Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation, Molecular Biology of the Cell, vol.20, issue.17, pp.3840-3850, 2009.
DOI : 10.1091/mbc.E09-02-0146

N. Cougot, S. Babajko, and B. Seraphin, Cytoplasmic foci are sites of mRNA decay in human cells, The Journal of Cell Biology, vol.115, issue.1, pp.31-40, 2004.
DOI : 10.1016/S0962-8924(01)01982-1

M. A. Andrei, D. Ingelfinger, R. Heintzmann, T. Achsel, R. Rivera-pomar et al., A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies, RNA, vol.11, issue.5, pp.717-727, 2005.
DOI : 10.1261/rna.2340405

A. P. Petit, L. Wohlbold, P. Bawankar, E. Huntzinger, S. Schmidt et al., The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4???NOT deadenylase complex, Nucleic Acids Research, vol.40, issue.21, pp.11058-11072, 2012.
DOI : 10.1093/nar/gks883

J. Basquin, V. V. Roudko, M. Rode, C. Basquin, B. Seraphin et al., Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction, Molecular Cell, vol.48, issue.2, pp.207-218, 2012.
DOI : 10.1016/j.molcel.2012.08.014

N. Ezzeddine, C. Y. Chen, and A. B. Shyu, Evidence Providing New Insights into TOB-Promoted Deadenylation and Supporting a Link between TOB's Deadenylation-Enhancing and Antiproliferative Activities, Molecular and Cellular Biology, vol.32, issue.6, pp.1089-1098, 2012.
DOI : 10.1128/MCB.06370-11
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295015

Y. Funakoshi, Y. Doi, N. Hosoda, N. Uchida, M. Osawa et al., Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases, Genes & Development, vol.21, issue.23, pp.3135-3148, 2007.
DOI : 10.1101/gad.1597707

Y. Bai, C. Salvadore, Y. C. Chiang, M. A. Collart, H. Y. Liu et al., The CCR4 and CAF1 Proteins of the CCR4-NOT Complex Are Physically and Functionally Separated from NOT2, NOT4, and NOT5, Molecular and Cellular Biology, vol.19, issue.10, pp.6642-6651, 1999.
DOI : 10.1128/MCB.19.10.6642

D. Y. Lee, I. Ianculescu, D. Purcell, X. Zhang, X. Cheng et al., Surface-Scanning Mutational Analysis of Protein Arginine Methyltransferase 1: Roles of Specific Amino Acids in Methyltransferase Substrate Specificity, Oligomerization, and Coactivator Function, Molecular Endocrinology, vol.21, issue.6, pp.1381-1393, 2007.
DOI : 10.1210/me.2006-0389

J. Cote, F. M. Boisvert, M. C. Boulanger, M. T. Bedford, and S. Richard, Sam68 RNA Binding Protein Is an In Vivo Substrate for Protein Arginine N-Methyltransferase 1, Molecular Biology of the Cell, vol.14, issue.1, pp.274-287, 2003.
DOI : 10.1091/mbc.E02-08-0484

T. Chen, F. M. Boisvert, D. P. Bazett-jones, and S. Richard, A Role for the GSG Domain in Localizing Sam68 to Novel Nuclear Structures in Cancer Cell Lines, Molecular Biology of the Cell, vol.10, issue.9, pp.3015-3033, 1999.
DOI : 10.1091/mbc.10.9.3015

J. Rho, S. Choi, C. R. Jung, and D. S. Im, Arginine methylation of Sam68 and SLM proteins negatively regulates their poly(U) RNA binding activity, Archives of Biochemistry and Biophysics, vol.466, issue.1, pp.49-57, 2007.
DOI : 10.1016/j.abb.2007.07.017

P. Frisone, D. Pradella, D. Matteo, A. Belloni, E. Ghigna et al., SAM68: Signal Transduction and RNA Metabolism in Human Cancer, BioMed Research International, vol.115, issue.3, p.528954, 2015.
DOI : 10.1093/nar/gku561
URL : http://doi.org/10.1155/2015/528954

N. Matter, P. Herrlich, and H. Konig, Signal-dependent regulation of splicing via phosphorylation of Sam68, Nature, vol.11, issue.6916, pp.691-695, 2002.
DOI : 10.1074/jbc.M004692200

O. Stoss, M. Olbrich, A. M. Hartmann, H. Konig, J. Memmott et al., The STAR/GSG Family Protein rSLM-2 Regulates the Selection of Alternative Splice Sites, Journal of Biological Chemistry, vol.1998, issue.12, pp.8665-8673, 2001.
DOI : 10.1006/bbrc.1994.1329

H. Ponta, L. Sherman, and P. A. Herrlich, CD44: From adhesion molecules to signalling regulators, Nature Reviews Molecular Cell Biology, vol.4, issue.1, pp.33-45, 2003.
DOI : 10.1038/nrm1004

P. Bielli, R. Busa, M. P. Paronetto, and C. Sette, The RNA-binding protein Sam68 is a multifunctional player in human cancer, Endocrine Related Cancer, vol.18, issue.4, pp.91-102, 2011.
DOI : 10.1530/ERC-11-0041

T. B. Nicholson, T. Chen, and S. Richard, The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation, Pharmacological Research, vol.60, issue.6, pp.466-474, 2009.
DOI : 10.1016/j.phrs.2009.07.006

L. Prochazka, R. Tesarik, and J. Turanek, Regulation of alternative splicing of CD44 in cancer, Cellular Signalling, vol.26, issue.10, pp.2234-2239, 2014.
DOI : 10.1016/j.cellsig.2014.07.011

B. Stupfler, C. Birck, B. Seraphin, and F. Mauxion, BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation, Nature Communications, vol.10, 2016.
DOI : 10.4161/rna.23065
URL : http://doi.org/10.1038/ncomms10811

F. Mauxion, C. Faux, and B. Seraphin, The BTG2 protein is a general activator of mRNA deadenylation, The EMBO Journal, vol.133, issue.7, pp.1039-1048, 2008.
DOI : 10.1128/MCB.10.5.2269

M. Nowotny and W. Yang, Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release, The EMBO Journal, vol.3, issue.9, pp.1924-1933, 2006.
DOI : 10.1038/sj.emboj.7601076

N. Ezzeddine, T. C. Chang, W. Zhu, A. Yamashita, C. Y. Chen et al., Human TOB, an Antiproliferative Transcription Factor, Is a Poly(A)-Binding Protein-Dependent Positive Regulator of Cytoplasmic mRNA Deadenylation, Molecular and Cellular Biology, vol.27, issue.22, pp.7791-7801, 2007.
DOI : 10.1128/MCB.01254-07

K. Okochi, T. Suzuki, J. Inoue, S. Matsuda, and T. Yamamoto, Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control, Genes to Cells, vol.17, issue.2, pp.151-163, 2005.
DOI : 10.1128/MCB.15.12.6770

K. Nishida, M. Horiuchi, N. N. Noda, K. Takahasi, N. Iwasaki et al., Crystallization and preliminary crystallographic analysis of the Tob???hCaf1 complex, Acta Crystallographica Section F Structural Biology and Crystallization Communications, vol.63, issue.12, pp.1061-1063, 2007.
DOI : 10.1107/S1744309107057466

R. Doidge, S. Mittal, A. Aslam, and G. S. Winkler, The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex, PLoS ONE, vol.280, issue.12, p.51331, 2012.
DOI : 10.1371/journal.pone.0051331.s004

T. Miyasaka, M. Morita, K. Ito, T. Suzuki, H. Fukuda et al., Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex, Cancer Science, vol.92, issue.4, pp.755-761, 2008.
DOI : 10.1084/jem.20030616

M. Horiuchi, K. Takeuchi, N. Noda, N. Muroya, T. Suzuki et al., Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex, Journal of Biological Chemistry, vol.269, issue.19, pp.13244-13255, 2009.
DOI : 10.1074/jbc.M609413200

J. Rappsilber, W. J. Friesen, S. Paushkin, G. Dreyfuss, and M. Mann, Detection of Arginine Dimethylated Peptides by Parallel Precursor Ion Scanning Mass Spectrometry in Positive Ion Mode, Analytical Chemistry, vol.75, issue.13, pp.3107-3114, 2003.
DOI : 10.1021/ac026283q

A. Yamashita, T. C. Chang, Y. Yamashita, W. Zhu, Z. Zhong et al., Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover, Nature Structural & Molecular Biology, vol.17, issue.12, pp.1054-1063, 2005.
DOI : 10.1128/MCB.14.12.8471

A. P. Snijders, G. M. Hautbergue, A. Bloom, J. C. Williamson, T. C. Minshull et al., Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA, RNA, vol.21, issue.3, pp.347-359, 2015.
DOI : 10.1261/rna.045138.114

M. C. Yu, F. Bachand, A. E. Mcbride, S. Komili, J. M. Casolari et al., Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors, Genes & Development, vol.18, issue.16, pp.2024-2035, 2004.
DOI : 10.1101/gad.1223204
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514182

M. C. Yu, The Role of Protein Arginine Methylation in mRNP Dynamics, Molecular Biology International, vol.58, issue.2, p.163827, 2011.
DOI : 10.1021/bi002631b

F. Faraji, Y. Hu, H. H. Yang, M. P. Lee, G. S. Winkler et al., Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7, PLOS Genetics, vol.8, issue.9, p.1005820, 2016.
DOI : 10.1371/journal.pgen.1005820.s011

S. M. Weis and D. A. Cheresh, alphaV integrins in angiogenesis and cancer. Cold Spring Harb, Perspect. Med, vol.1, p.6478, 2011.
DOI : 10.1101/cshperspect.a006478
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234453