. Dcm and J. =. Then-dcmt, Yield: 560 mg (99 %) Mp: 57 °C. 1 H NMR (400 MHz, MeOD) ? 0.73 (t05 (s, 12H), Hz, 3H), 1.10 (m, 16H), 1.54 (q, J = 7.5 Hz, 2H) 1H), 7.27 (s, 2H), 7.99 (s, 1H). 13 C NMR (101 MHz, MeOD) ? 13, pp.2918-716, 1097.

J. =. (-t, H) 13 C NMR (101 MHz, MeOD) 13, 2H), 3.96 (dd, J = 15.3, 7.2 Hz, 2H) found: 554. 2283 (M-Cl -) (calc for C26H45N3O3Pd, pp.2868-2870, 1049.

1. Hz, 1H, 1 st diastereomer), 6.99 (s, 1H, 1 st diastereomer), 7.00 (s, 1H, 2 nd diastereomer), 7.37 (s, 1H, 1 st diastereomer), 7.39 (s, 1H, 2 nd diastereomer) 13 C NMR (101 MHz, CDCl3) ? 13, st and 2 nd diastereomers), pp.32-33

M. E. Wilson and G. M. Whitesides, nd diastereomer), 135.2, 146, 171.6 (1 st and 2 nd References [1] J. Bos, G. Roelfes, pp.135-143, 1978.

J. Coquiere, J. Bos, G. Beld, and . Roelfes, Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold, Angewandte Chemie International Edition, vol.127, issue.28, pp.5159-5162, 2009.
DOI : 10.1002/anie.200901134

P. J. Deuss, R. Den-heeten, W. Laan, and P. C. Kamer, Bioinspired Catalyst Design and Artificial Metalloenzymes, Chemistry - A European Journal, vol.453, issue.17, pp.4680-4698, 2011.
DOI : 10.1038/nature06879

M. Filice, O. Romero, A. Aires, J. M. Guisan, A. Rumbero et al., Preparation of an Immobilized Lipase-Palladium Artificial Metalloenzyme as Catalyst in the Heck Reaction: Role of the Solid Phase, Advanced Synthesis & Catalysis, vol.10, issue.12, pp.2687-2696, 2015.
DOI : 10.1016/0141-0229(88)90018-X

W. Laan, B. K. Munoz, R. Den-heeten, and P. C. Kamer, Artificial Metalloenzymes through Cysteine-Selective Conjugation of Phosphines to Photoactive Yellow Protein, ChemBioChem, vol.69, issue.9, pp.1236-1239, 2010.
DOI : 10.1002/cbic.201000159

J. Abe, M. Niemeyer, Y. Abe, T. Takezawa, T. Ueno et al., Control of the Coordination Structure of Organometallic Palladium Complexes in an apo-Ferritin Cage, Journal of the American Chemical Society, vol.130, issue.32, pp.10512-10514, 2008.
DOI : 10.1021/ja802463a

J. Pierron, C. Malan, M. Creus, J. Gradinaru, I. Hafner et al., Artificial Metalloenzymes for Asymmetric Allylic Alkylation on the Basis of the Biotin???Avidin Technology, Angewandte Chemie International Edition, vol.14, issue.4, pp.701-705, 2008.
DOI : 10.1007/978-3-642-18537-3

H. Chatterjee, J. Mallin, J. Klehr, A. D. Vallapurackal, L. Finke et al., An enantioselective artificial Suzukiase based on the biotin???streptavidin technology, Chem. Sci., vol.115, issue.1, pp.673-677, 2016.
DOI : 10.1021/acs.chemrev.5b00162

URL : http://pubs.rsc.org/en/content/articlepdf/2016/sc/c5sc03116h

N. Selander and K. J. Szabó, Catalysis by Palladium Pincer Complexes, Chemical Reviews, vol.111, issue.3, pp.2048-2076, 2011.
DOI : 10.1021/cr1002112

URL : http://doi.org/10.1021/cr1002112

P. Steenwinkel, R. A. Gossage, and G. Van-koten, Recent Findings in Cyclometallation of meta-Substituted Aryl Ligands by Platinum Group Metal Complexes by Caryl-R Bond Activation (R=H, CR3, SiR3), Chemistry - A European Journal, vol.118, issue.5, pp.759-762, 1998.
DOI : 10.1002/(SICI)1521-3765(19980515)4:5<759::AID-CHEM759>3.0.CO;2-K

B. Soro, S. Stoccoro, G. Minghetti, A. Zucca, M. A. Cinellu et al., ]. Catalytic Activity in the Heck Reaction, Organometallics, vol.24, issue.1, pp.53-61, 2005.
DOI : 10.1021/om040102o

A. Taheri-kafrani, Y. Choiset, D. A. Faizullin, Y. F. Zuev, V. V. Bezuglov et al., Interactions of ??-lactoglobulin with serotonin and arachidonyl serotonin, Biopolymers, vol.56, issue.12, pp.871-880, 2011.
DOI : 10.1021/jf801383m

O. Nicolotti, I. Giangreco, T. F. Miscioscia, A. Carotti-b-)-o, T. F. Nicolotti et al., Improving Quantitative Structure???Activity Relationships through Multiobjective Optimization, Journal of Chemical Information and Modeling, vol.49, issue.10, pp.2290-2302, 2008.
DOI : 10.1021/ci9002409

M. V. Cherrier, S. Engilberge, P. Amara, A. Chevalley, M. Salmain et al., Structural Basis for Enantioselectivity in the Transfer Hydrogenation of a Ketone Catalyzed by an Artificial Metalloenzyme, European Journal of Inorganic Chemistry, vol.16, issue.21, pp.3596-3600
DOI : 10.1021/ja00160a020

A. Divsalar, A. A. Saboury, H. Mansoori-torshizi, and F. Ahmad, Design, Synthesis, and Biological Evaluation of a New Palladium(II) Complex: ??-Lactoglobulin and K562 as Targets, The Journal of Physical Chemistry B, vol.114, issue.10, pp.3639-3647, 2010.
DOI : 10.1021/jp909143b

D. M. Grove, G. Van-koten, J. N. Louwen, J. G. Noltes, A. L. Spek et al., Trans-2,6-bis[(dimethylamino)methyl]phenyl-N,N',C complexes of palladium(II) and platinum(II). Crystal structure of [PtI[MeC6H3(CH2NMe2)2-o,o']]BF4: a cyclohexadienyl carbonium ion with a .sigma.-bonded metal substituent, Journal of the American Chemical Society, vol.104, issue.24, pp.6609-6616, 1982.
DOI : 10.1021/ja00388a022

A. R. Katritzky, H. He, and K. Suzuki, -Acylbenzotriazoles:?? Neutral Acylating Reagents for the Preparation of Primary, Secondary, and Tertiary Amides, The Journal of Organic Chemistry, vol.65, issue.24, pp.8210-8213, 2000.
DOI : 10.1021/jo000792f