Cardiometabolic risk factors in primary centred and rotator cuff-related shoulder osteoarthritis: a comparative study

Abstract : Background Risk: factors for shoulder osteoarthritis (SOA) have been poorly studied. SOA has two anatomical subtypes: primary centred SOA (centred SOA) and rotator cuff-related OA (non-centred SOA). We examined whether cardiometabolic risk factors are preferentially associated with centred than mechanical-induced non-centred SOA. Methods: This 2004–2012 retrospective multicentric study included patients with SOA. Data on clinical characteristics, especially cardiometabolic risk factors, were collected. We compared patients with radiographic-centred and non-centred SOA and tested the association between cardiometabolic risk factors and subtypes of SOA. Results: We included 147 patients (101 women (68.7%); mean age 75.8±10 years); 99 had centred SOA. As compared with patients with non-centred SOA, those with centred SOA were older (77.5±9 vs 72.4±11 years; p=0.004) with no difference in cardiometabolic disturbances or their accumulation. Multivariable analyses indicated that older age was independently associated with centred SOA (OR 1.06;95% CI 1.02 to 1.1; p=0.004), and cardiovascular diseases were less associated with this subtype (OR 0.27; 95% CI 0.089 to 0.824; p=0.02) than with the non-centred one. Conclusion: Cardiometabolic risk factors were not more prevalent with primary centred than rotator cuff-related SOA. They may participate in the pathophysiology of both SOA subtypes through cartilage and tendon disruption.
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Soumis le : mercredi 4 octobre 2017 - 10:12:58
Dernière modification le : mardi 10 octobre 2017 - 13:46:27

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Pierre-Antoine Juge, Laure Berard, Salma Kotti, Levon Doursounian, Alain Sautet, et al.. Cardiometabolic risk factors in primary centred and rotator cuff-related shoulder osteoarthritis: a comparative study. RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2017, 3 (1), pp.e000429. 〈10.1136/rmdopen-2016-000429〉. 〈hal-01609882〉

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