A. Aguirre, J. Dupree, J. Mangin, and V. Gallo, A functional role for EGFR signaling in myelination and remyelination, Nature Neuroscience, vol.22, issue.8, pp.990-1002, 2007.
DOI : 10.1046/j.0305-1846.2001.00301.x

A. Aguirre and V. Gallo, Reduced EGFR signaling in progenitor cells of the adult subventricular zone attenuates oligodendrogenesis after demyelination, Neuron Glia Biology, vol.3, issue.03, pp.209-220, 2007.
DOI : 10.1017/S1740925X08000082

B. Barres, M. Lazar, and M. Raff, A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development, Development, vol.120, pp.1097-1108, 1994.

A. Bergmann, M. Tugentman, B. Shilo, and H. Steller, Regulation of Cell Number by MAPK-Dependent Control of Apoptosis, Developmental Cell, vol.2, issue.2, pp.159-170, 1016.
DOI : 10.1016/S1534-5807(02)00116-8

N. Billon, C. Jolicoeur, Y. Tokumoto, B. Vennströ-m, and M. Raff, Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRalpha1), The EMBO Journal, vol.21, issue.23, pp.6452-6460, 2002.
DOI : 10.1093/emboj/cdf662

B. Brousse, K. Magalon, P. Durbec, and M. Cayre, Region and dynamic specificities of adult neural stem cells and oligodendrocyte precursors in myelin regeneration in the mouse brain, Biology Open, vol.4, issue.8, pp.980-992, 2015.
DOI : 10.1242/bio.012773

URL : https://hal.archives-ouvertes.fr/hal-01431213

C. Buckley, A. Marguerie, A. Roach, P. Goldsmith, A. Fleming et al., Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects, Neuropharmacology, vol.59, issue.3, pp.149-159, 2010.
DOI : 10.1016/j.neuropharm.2010.04.014

M. Bunge, R. Bunge, and H. Ris, ULTRASTRUCTURAL STUDY OF REMYELINATION IN AN EXPERIMENTAL LESION IN ADULT CAT SPINAL CORD, The Journal of Cell Biology, vol.10, issue.1, pp.67-94, 1961.
DOI : 10.1083/jcb.10.1.67

D. Crawford, M. Mangiardi, X. Xia, H. Ló-pez-valdé-s, and S. Tiwari-woodruff, Functional recovery of callosal axons following demyelination: a critical window, Neuroscience, vol.164, issue.4, pp.1407-1421, 2009.
DOI : 10.1016/j.neuroscience.2009.09.069

M. Dawson, A. Polito, J. Levine, and R. Reynolds, NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS, Molecular and Cellular Neuroscience, vol.24, issue.2, pp.476-488, 1016.
DOI : 10.1016/S1044-7431(03)00210-0

S. Decherf, I. Seugnet, S. Kouidhi, A. Lopez-juarez, M. Clerget-froidevaux et al., Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression, Proceedings of the National Academy of Sciences, vol.35, issue.9, pp.4471-4476, 2010.
DOI : 10.1093/nar/gkm152

V. Deshmukh, V. Tardif, C. Lyssiotis, C. Green, B. Kerman et al., A regenerative approach to the treatment of multiple sclerosis, Nature, vol.34, issue.7471, pp.327-332, 2013.
DOI : 10.1016/j.mcn.2006.11.008

F. Doetsch, I. Caillé, D. Lim, J. García-verdugo, and A. Alvarez-buylla, Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain, Cell, vol.97, issue.6, pp.703-716, 1016.
DOI : 10.1016/S0092-8674(00)80783-7

F. Doetsch, L. Petreanu, I. Caille, J. Garcia-verdugo, and A. Alvarez-buylla, EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells, Neuron, vol.36, issue.6, pp.1021-1034, 1016.
DOI : 10.1016/S0896-6273(02)01133-9

J. Dugas, A. Ibrahim, and B. Barres, The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration, Molecular and Cellular Neuroscience, vol.50, issue.1, pp.45-57, 2012.
DOI : 10.1016/j.mcn.2012.03.007

R. Dutta and B. Trapp, Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis, Progress in Neurobiology, vol.93, issue.1, pp.1-12, 2011.
DOI : 10.1016/j.pneurobio.2010.09.005

E. Waly, B. Macchi, M. Cayre, M. Durbec, and P. , Oligodendrogenesis in the normal and pathological central nervous system, Frontiers in Neuroscience, vol.8, pp.24-971048, 2014.

R. Franklin, Why does remyelination fail in multiple sclerosis?, Nature Reviews Neuroscience, vol.105, issue.9, pp.705-714, 2002.
DOI : 10.1002/(SICI)1097-4547(19991015)58:2<207::AID-JNR1>3.0.CO;2-1

R. Franklin, Regenerative Medicines for Remyelination: From Aspiration to Reality, Cell Stem Cell, vol.16, issue.6, pp.576-577, 2015.
DOI : 10.1016/j.stem.2015.05.010

K. Gauthier, M. Plateroti, C. Harvey, G. Williams, R. Weiss et al., Genetic Analysis Reveals Different Functions for the Products of the Thyroid Hormone Receptor ?? Locus, Molecular and Cellular Biology, vol.21, issue.14, pp.4748-4760, 2001.
DOI : 10.1128/MCB.21.14.4748-4760.2001

URL : https://hal.archives-ouvertes.fr/ensl-00000006

K. Giesen, U. Lammel, D. Langehans, K. Krukkert, I. Bunse et al., Regulation of glial cell number and differentiation by ecdysone and Fos signaling, Mechanisms of Development, vol.120, issue.4, pp.401-413, 2003.
DOI : 10.1016/S0925-4773(03)00009-1

D. Goula, J. Remy, P. Erbacher, M. Wasowicz, G. Levi et al., Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system, Gene Therapy, vol.5, issue.5, pp.712-717, 1998.
DOI : 10.1038/sj.gt.3300635

T. Hamilton, R. Klinghoffer, P. Corrin, and P. Soriano, Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms, Molecular and Cellular Biology, vol.23, issue.11, pp.4013-4025, 2003.
DOI : 10.1128/MCB.23.11.4013-4025.2003

Z. Hassani, J. Franç-ois, G. Alfama, G. Dubois, M. Paris et al., A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain, Nucleic Acids Research, vol.35, issue.9, p.17426128, 2007.
DOI : 10.1093/nar/gkm152

URL : https://hal.archives-ouvertes.fr/hal-00179406

A. Hidalgo, E. Kinrade, and M. Georgiou, The Drosophila Neuregulin Vein Maintains Glial Survival during Axon Guidance in the CNS, Developmental Cell, vol.1, issue.5, pp.679-690, 1016.
DOI : 10.1016/S1534-5807(01)00074-0

R. Kapoor, S. Fanibunda, L. Desouza, S. Guha, and V. Vaidya, Perspectives on thyroid hormone action in adult neurogenesis, Journal of Neurochemistry, vol.16, issue.9399, pp.599-616, 2015.
DOI : 10.1111/j.1365-2826.2004.01243.x

H. Keirstead and W. Blakemore, The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination Advances in experimental medicine and biology 468 DOI: https://doi, pp.183-197, 1999.

G. Lemkine, S. Mantero, C. Migné, A. Raji, D. Goula et al., Preferential Transfection of Adult Mouse Neural Stem Cells and Their Immediate Progeny in Vivo with Polyethylenimine, Molecular and Cellular Neuroscience, vol.19, issue.2, pp.165-174, 2002.
DOI : 10.1006/mcne.2001.1084

G. Lemkine, R. A. Alfama, G. Turque, N. Hassani, Z. et al., Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor, The FASEB Journal, vol.19, pp.863-865, 2005.
DOI : 10.1096/fj.04-2916fje

URL : https://hal.archives-ouvertes.fr/hal-00093475

C. Lois and A. Alvarez-buylla, Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia., Proceedings of the National Academy of Sciences, vol.90, issue.5, pp.2074-2077, 1993.
DOI : 10.1073/pnas.90.5.2074

A. Ló-pez-juá-rez, S. Remaud, Z. Hassani, P. Jolivet, P. Simons et al., Thyroid Hormone Signaling Acts as a Neurogenic Switch by Repressing Sox2 in the Adult Neural Stem Cell Niche, Cell Stem Cell, vol.10, issue.5, pp.531-543, 2012.
DOI : 10.1016/j.stem.2012.04.008

Q. Lu, Y. D. Alberta, J. Zhu, Z. Pawlitzky, I. Chan et al., Sonic Hedgehog???Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System, Neuron, vol.25, issue.2, pp.317-329, 2000.
DOI : 10.1016/S0896-6273(00)80897-1

S. Ludwin, Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity Laboratory investigation, pp.597-612, 1978.

P. Macchia, Y. Takeuchi, T. Kawai, K. Cua, K. Gauthier et al., Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha, Proceedings of the National Academy of Sciences, vol.98, issue.1, pp.349-354, 2001.
DOI : 10.1073/pnas.011306998

URL : https://hal.archives-ouvertes.fr/hal-00023826

D. Mahad, B. Trapp, and H. Lassmann, Pathological mechanisms in progressive multiple sclerosis, The Lancet Neurology, vol.14, issue.2, pp.183-193, 1016.
DOI : 10.1016/S1474-4422(14)70256-X

M. Mavinakere, J. Powers, K. Subramanian, V. Roggero, and L. Allison, Multiple Novel Signals Mediate Thyroid Hormone Receptor Nuclear Import and Export, Journal of Biological Chemistry, vol.15, issue.37, pp.31280-31297, 2012.
DOI : 10.1093/bioinformatics/btm404

F. Mei, S. Fancy, Y. Shen, J. Niu, C. Zhao et al., Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis, Nature Medicine, vol.18, issue.8, pp.954-960, 2014.
DOI : 10.1002/dneu.20976

F. Mei, K. Lehmann-horn, Y. Shen, K. Rankin, K. Stebbins et al., Author response, eLife, vol.138, p.27671734, 2016.
DOI : 10.7554/eLife.18246.013

B. Menn, J. Garcia-verdugo, C. Yaschine, O. Gonzalez-perez, D. Rowitch et al., Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain, Journal of Neuroscience, vol.26, issue.30, pp.7907-7918, 2006.
DOI : 10.1523/JNEUROSCI.1299-06.2006

J. Miller, S. Ding, S. Sunkin, K. Smith, L. Ng et al., Transcriptional landscape of the prenatal human brain, Nature, vol.5, issue.7495, pp.199-206, 2014.
DOI : 10.1186/1471-2105-5-17

B. Nait-oumesmar, L. Decker, F. Lachapelle, V. Avellana-adalid, C. Bachelin et al., Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination, European Journal of Neuroscience, vol.4, issue.12, pp.4357-4366, 1999.
DOI : 10.1002/glia.440040509

B. Nait-oumesmar, N. Picard-riera, C. Kerninon, L. Decker, D. Seilhean et al., Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors, Proceedings of the National Academy of Sciences, vol.3, issue.1, pp.4694-4699, 2007.
DOI : 10.1038/nm974

F. Najm, M. Madhavan, A. Zaremba, E. Shick, R. Karl et al., Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo, Nature, vol.31, issue.7555, pp.216-220, 2015.
DOI : 10.1038/nbt.2450

J. Ortega, . Radonjic´nvradonjic´radonjic´nv, and N. Zecevic, Sonic hedgehog promotes generation and maintenance of human forebrain Olig2 progenitors, Frontiers in Cellular Neuroscience, vol.7, p.24379757, 2013.
DOI : 10.3389/fncel.2013.00254

P. Patrikios, C. Stadelmann, A. Kutzelnigg, H. Rauschka, M. Schmidbauer et al., Remyelination is extensive in a subset of multiple sclerosis patients, Brain, vol.129, issue.12, pp.3165-3172, 2006.
DOI : 10.1093/brain/awl217

O. Pé-rier and A. Gré-goire, ELECTRON MICROSCOPIC FEATURES OF MULTIPLE SCLEROSIS LESIONS, Brain, vol.88, issue.5, pp.937-952, 1965.
DOI : 10.1093/brain/88.5.937

H. Reichert, Evolutionary conservation of mechanisms for neural regionalization, proliferation and interconnection in brain development, Biology Letters, vol.18, issue.1, pp.112-116, 2009.
DOI : 10.1016/j.conb.2008.05.002

S. Remaud, J. Gothié, G. Morvan-dubois, and B. Demeneix, Thyroid Hormone Signaling and Adult Neurogenesis in Mammals, Frontiers in Endocrinology, vol.24, issue.8, p.24808891, 2014.
DOI : 10.1210/me.2009-0298

A. Sahel, F. Ortiz, C. Kerninon, P. Maldonado, M. Angulo et al., Alteration of synaptic connectivity of oligodendrocyte precursor cells following demyelination, Frontiers in Cellular Neuroscience, vol.10, issue.255, p.25852473, 2015.
DOI : 10.1038/nn1854

URL : https://hal.archives-ouvertes.fr/hal-01215487

T. Sapir, D. Horesh, M. Caspi, R. Atlas, H. Burgess et al., Doublecortin mutations cluster in evolutionarily conserved functional domains, Human Molecular Genetics, vol.9, issue.5, pp.703-712, 2000.
DOI : 10.1093/hmg/9.5.703

J. Scafidi, T. Hammond, S. Scafidi, J. Ritter, B. Jablonska et al., Intranasal epidermal growth factor treatment rescues neonatal brain injury, Nature, vol.114, issue.7487, pp.230-234, 2014.
DOI : 10.1111/j.1471-4159.2010.06807.x

S. Germain, D. Galton, V. Hernandez, and A. , Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges, Endocrinology, vol.150, issue.3, pp.1097-1107, 2009.
DOI : 10.1210/en.2008-1588

M. Stidworthy, S. Genoud, U. Suter, N. Mantei, and R. Franklin, Quantifying the Early Stages of Remyelination Following Cuprizone-induced Demyelination, Brain Pathology, vol.25, issue.3, pp.329-339, 2003.
DOI : 10.4049/jimmunol.167.5.2964

C. Stolt, P. Lommes, R. Friedrich, and M. Wegner, Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy, Development, vol.131, issue.10, pp.2349-2358, 2004.
DOI : 10.1242/dev.01114

Y. Sun, S. Goderie, and S. Temple, Asymmetric Distribution of EGFR Receptor during Mitosis Generates Diverse CNS Progenitor Cells, Neuron, vol.45, issue.6, pp.873-886, 2005.
DOI : 10.1016/j.neuron.2005.01.045

S. Suzuki and J. Goldman, Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: a dynamic study of glial and neuronal progenitor migration, Journal of Neuroscience, vol.23, pp.4240-4250, 2003.

R. Tripathi, L. Rivers, K. Young, F. Jamen, and W. Richardson, NG2 Glia Generate New Oligodendrocytes But Few Astrocytes in a Murine Experimental Autoimmune Encephalomyelitis Model of Demyelinating Disease, Journal of Neuroscience, vol.30, issue.48, pp.16383-16390, 2010.
DOI : 10.1523/JNEUROSCI.3411-10.2010

G. Wolswijk and M. Noble, Identification of an adult-specific glial progenitor cell DOI: https://doi.org/10, Cell Differentiation and Development, vol.105, issue.89, pp.203-4000922, 1016.

Y. Xing, P. Rö-th, J. Stratton, B. Chuang, J. Danne et al., Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination, Journal of Neuroscience, vol.34, issue.42, pp.14128-14146, 2014.
DOI : 10.1523/JNEUROSCI.3491-13.2014

J. Xu, K. Thompson, L. Shephard, L. Hudson, and G. Gill, T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites, The Journal of biological chemistry, vol.268, pp.16065-16073, 1993.

N. Zak and B. Shilo, Biochemical properties of the Drosophila EGF receptor homolog (DER) protein, Oncogene, vol.5, pp.1589-1593, 1990.

Y. Zhang, R. Wang, Q. Liu, H. Zhang, F. Liao et al., Presenilin/??-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression, Proceedings of the National Academy of Sciences, vol.94, issue.8, pp.10613-10618, 2007.
DOI : 10.1073/pnas.94.8.3748