Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain

Abstract : Our objective was to determine whether controlled reflow on one side and/or the other side after bilateral carotid occlusion release could reduce cell death in focal ischemic P14 rats. Arterial blood flow was measured using ultrason-ography. Cell death, inflammation and nitrotyrosine were measured using immunofluorescence. When reflow was first induced in the contralateral side, we observed improved outcome markers compared with those when reflow was first induced in the ipsilateral side and/or simultaneous reflow was induced in both sides. Our data suggest that progressive rerouting of arterial flow through the circle of Willis toward the ischemic site reduced cell death.
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Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2017, 37 (9), pp.3091-3096. 〈10.1177/0271678X17719614〉
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Philippe Bonnin, Julien Pansiot, Elise Paven, Maxime Eloi, Sylvain Renolleau, et al.. Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2017, 37 (9), pp.3091-3096. 〈10.1177/0271678X17719614〉. 〈hal-01614918〉

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