O. Hardiman, L. Van-den-berg, and M. Kiernan, Clinical diagnosis and management of amyotrophic lateral sclerosis, Nature Reviews Neurology, vol.11, issue.11, 2011.
DOI : 10.3109/17482968.2010.487532

M. Turner, M. Kiernan, P. Leigh, and K. Talbot, Biomarkers in amyotrophic lateral sclerosis, The Lancet Neurology, vol.8, issue.1, pp.94-10970293, 2009.
DOI : 10.1016/S1474-4422(08)70293-X

R. Mitchell, Z. Simmons, J. Beard, H. Stephens, and J. Connor, Plasma biomarkers associated with ALS and their relationship to iron homeostasis, Muscle & Nerve, vol.3, issue.Suppl 3, pp.95-103, 2010.
DOI : 10.4049/jimmunol.178.1.39

T. Kruger, J. Lautenschlager, J. Grosskreutz, and H. Rhode, Proteome analysis of body fluids for amyotrophic lateral sclerosis (ALS) biomarker discovery, Proteomics Clin Appl, 2012.

H. Ryberg, J. An, S. Darko, J. Lustgarten, and M. Jaffa, Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics, Muscle & Nerve, vol.40, issue.1, p.20583124, 2010.
DOI : 10.1016/S0925-4439(02)00156-4

J. Brettschneider, V. Lehmensiek, H. Mogel, M. Pfeifle, and J. Dorst, Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS), Neuroscience Letters, vol.468, issue.1, pp.23-27, 2010.
DOI : 10.1016/j.neulet.2009.10.053

J. Ganesalingam, A. J. Shaw, C. Shaw, G. Lacomis, and D. , Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS, Journal of Neurochemistry, vol.154, issue.3, pp.528-537, 2011.
DOI : 10.1016/S0002-9440(10)65340-0

J. Villanueva, J. Philip, D. Entenberg, C. Chaparro, and M. Tanwar, Serum peptide profiling by magnetic particle-assisted, 2004.
DOI : 10.1021/ac0352171

Y. Li, J. Wang, X. Zheng, Y. Zhang, and X. Li, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Combined with Magnetic Beads for Detecting Serum Protein Biomarkers in Parkinson???s Disease, European Neurology, vol.65, issue.2, pp.105-11110, 2011.
DOI : 10.1159/000323427

X. Zhang, Z. Yuan, B. Shen, M. Zhu, and C. Liu, Discovery of serum protein biomarkers in rheumatoid arthritis using MALDI-TOF-MS combined with magnetic beads, Clinical and Experimental Medicine, vol.52, issue.3, pp.145-151, 2011.
DOI : 10.1002/art.21607

N. Von-neuhoff, T. Oumeraci, T. Wolf, K. Kollewe, and P. Bewerunge, Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic, PLoS ONE, vol.7, issue.9, p.22970211, 2012.
DOI : 10.1371/journal.pone.0044401.s005

A. Polpitiya, W. Qian, N. Jaitly, V. Petyuk, and J. Adkins, DAnTE: a statistical tool for quantitative analysis of -omics data, Bioinformatics, vol.24, issue.13, 2008.
DOI : 10.1093/bioinformatics/btn217

N. A. Keller, A. Kolker, E. Aebersold, and R. , A statistical model for identifying proteins by tandem mass spectrometry, Anal Chem, vol.75, issue.17, pp.4646-4658, 2003.

V. Silani, S. Messina, B. Poletti, C. Morelli, and A. Doretti, The diagnosis of Amyotrophic lateral sclerosis in 2010, Arch Ital Biol, vol.149, pp.5-27, 2011.

A. Rai, C. Gelfand, B. Haywood, D. Warunek, and Y. J. , HUPO Plasma Proteome Project specimen collection and handling: Towards the standardization of parameters for plasma proteome samples, PROTEOMICS, vol.42, issue.11, pp.3262-3277, 2005.
DOI : 10.2174/1386207013331246

J. Villanueva, D. Shaffer, J. Philip, C. Chaparro, and H. Erdjument-bromage, Differential exoprotease activities confer tumor-specific serum peptidome patterns, Journal of Clinical Investigation, vol.116, issue.1, pp.271-284, 2006.
DOI : 10.1172/JCI26022DS1

T. Liang, N. Wang, W. Li, A. Li, and J. Wang, Identification of complement C3f-desArg and its derivative for acute leukemia diagnosis and minimal residual disease assessment, PROTEOMICS, vol.344, issue.1, pp.90-98, 2010.
DOI : 10.1002/pmic.200900513

Y. An, S. Bekesova, N. Edwards, and R. Goldman, Peptides in Low Molecular Weight Fraction of Serum Associated with Hepatocellular Carcinoma, Disease Markers, vol.29, issue.1, pp.11-20, 2010.
DOI : 10.1155/2010/681876

N. Kaneshiro, Y. Xiang, K. Nagai, M. Kurokawa, and K. Okamoto, Comprehensive analysis of short peptides in sera from patients with IgA nephropathy, Rapid Communications in Mass Spectrometry, vol.21, issue.23, 2009.
DOI : 10.1155/2006/174849

P. Nanni, Mass Spectrometry-Based Protein Profiling Strategies For Biomarker Discovery In Liver And Inflammatory Bowel Diseases, 2008.

Y. Kawashima, T. Fukutomi, T. Tomonaga, H. Takahashi, and F. Nomura, High-Yield Peptide-Extraction Method for the Discovery of Subnanomolar Biomarkers from Small Serum Samples, Journal of Proteome Research, vol.9, issue.4, pp.1694-1705, 2010.
DOI : 10.1021/pr9008018

A. Mcnicol and S. Israels, Beyond Hemostasis: The Role of Platelets in Inflammation, Malignancy and Infection, Cardiovascular & Hematological Disorders-Drug Targets, vol.8, issue.2, pp.99-117, 2008.
DOI : 10.2174/187152908784533739

G. Fiedler, A. Leichtle, J. Kase, S. Baumann, and U. Ceglarek, Serum Peptidome Profiling Revealed Platelet Factor 4 as a Potential Discriminating Peptide Associated with Pancreatic Cancer, Clinical Cancer Research, vol.15, issue.11, pp.3812-3819, 2009.
DOI : 10.1158/1078-0432.CCR-08-2701
URL : http://clincancerres.aacrjournals.org/content/clincanres/15/11/3812.full.pdf

S. Struyf, M. Burdick, P. Proost, J. Van-damme, and R. Strieter, Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis, Circulation Research, vol.95, issue.9, pp.855-857, 2004.
DOI : 10.1161/01.RES.0000146674.38319.07

J. Kim, J. Lee, S. Choi, E. Kim, and N. Jung, Quantitative pattern analysis of the N-terminally processed isoforms of platelet factor-4 in serum, Rapid Communications in Mass Spectrometry, vol.109, issue.4, pp.521-530, 2013.
DOI : 10.1182/blood-2006-10-052035

M. Kowalska, L. Rauova, and M. Poncz, Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis, Thrombosis Research, vol.125, issue.4, pp.292-296, 2010.
DOI : 10.1016/j.thromres.2009.11.023

J. Vandercappellen, J. Van-damme, and S. Struyf, The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer, Cytokine & Growth Factor Reviews, vol.22, issue.1, p.21111666, 2011.
DOI : 10.1016/j.cytogfr.2010.10.011

S. Aidoudi and A. Bikfalvi, nteraction of PF4 (CXCL4) with the vasculature: a role in atherosclerosis and angiogenesis, Thromb_Haemost, vol.104, pp.941-948, 2010.

P. Khansari and B. Sperlagh, Inflammation in neurological and psychiatric diseases, Inflammopharmacology, vol.7, issue.4, 2012.
DOI : 10.1016/j.nurt.2010.07.004

M. Evans, Y. Couch, N. Sibson, and M. Turner, Inflammation and neurovascular changes in amyotrophic lateral sclerosis, Molecular and Cellular Neuroscience, vol.53, pp.34-41, 2013.
DOI : 10.1016/j.mcn.2012.10.008

V. Bartanusz, D. Jezova, B. Alajajian, and M. Digicaylioglu, The bloodspinal cord barrier: morphology and clinical implications, Ann_Neurol, vol.2, pp.194-206, 2011.

R. Arhart, A possible haemodynamic mechanism for Amyotrophic Lateral Sclerosis, Medical Hypotheses, vol.75, issue.4, pp.341-346, 2010.
DOI : 10.1016/j.mehy.2010.03.017

M. Behari and M. Shrivastava, Role of platelets in neurodegenerative diseases: a universal pathophysiology, International Journal of Neuroscience, vol.139, issue.1, pp.287-299, 2013.
DOI : 10.1016/j.expneurol.2010.01.002

M. Shrivastava, T. Das, M. Behari, U. Pati, and S. Vivekanandhan, Ultrastructural Variations in Platelets and Platelet Mitochondria: A Novel Feature in Amyotrophic Lateral Sclerosis, Ultrastructural Pathology, vol.40, issue.6, p.21299344, 2011.
DOI : 10.1016/S0197-0186(01)00125-5

L. Dupuis, O. Spreux-varoquaux, G. Bensimon, P. Jullien, and L. Lacomblez, Platelet Serotonin Level Predicts Survival in Amyotrophic Lateral Sclerosis, PLoS ONE, vol.127, issue.10, p.20967129, 2010.
DOI : 10.1371/journal.pone.0013346.t003
URL : https://hal.archives-ouvertes.fr/inserm-00531253