D. H. Anderson, M. J. Radeke, N. B. Gallo, E. A. Chapin, P. T. Johnson et al., The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited, Progress in Retinal and Eye Research, vol.29, issue.2, pp.95-112, 2010.
DOI : 10.1016/j.preteyeres.2009.11.003

M. Chen, D. A. Copland, J. Zhao, J. Liu, J. V. Forrester et al., Persistent Inflammation Subverts Thrombospondin-1???Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation, The American Journal of Pathology, vol.180, issue.1, pp.235-245, 2012.
DOI : 10.1016/j.ajpath.2011.09.020

S. J. Clark, V. A. Higman, B. Mulloy, S. J. Perkins, S. M. Lea et al., His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form, Journal of Biological Chemistry, vol.4, issue.34, pp.24713-24720, 2006.
DOI : 10.1038/eye.1990.86

S. J. Clark, R. Perveen, S. Hakobyan, B. P. Morgan, R. B. Sim et al., Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina, Journal of Biological Chemistry, vol.177, issue.39, pp.30192-30202, 2010.
DOI : 10.1016/j.preteyeres.2009.11.003

C. Combadiè-re, C. Feumi, W. Raoul, N. Keller, M. Rodé-ro et al., CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration, Journal of Clinical Investigation, vol.117, issue.10, pp.2920-2928, 2007.
DOI : 10.1172/JCI31692DS1

M. Febbraio, D. P. Hajjar, and R. L. Silverstein, CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism, Journal of Clinical Investigation, vol.108, issue.6, pp.785-791, 2001.
DOI : 10.1172/JCI14006

L. G. Fritsche, R. N. Fariss, D. Stambolian, G. R. Abecasis, C. A. Curcio et al., Age-Related Macular Degeneration: Genetics and Biology Coming Together, Annual Review of Genomics and Human Genetics, vol.15, issue.1, pp.151-171, 2014.
DOI : 10.1146/annurev-genom-090413-025610

URL : http://europepmc.org/articles/pmc4217162?pdf=render

E. L. Gautier, T. Shay, J. Miller, M. Greter, C. Jakubzick et al., Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages, Nature Immunology, vol.18, issue.11, pp.1118-1128, 2012.
DOI : 10.1103/PhysRevLett.76.3251

E. L. Gautier, S. Ivanov, P. Lesnik, R. , and G. J. , Local apoptosis mediates clearance of macrophages from resolving inflammation in mice, Blood, vol.122, issue.15, pp.2714-2722, 2013.
DOI : 10.1182/blood-2013-01-478206

D. W. Gilroy, P. R. Colville-nash, D. Willis, J. Chivers, M. J. Paul-clark et al., Inducible cyclooxygenase may have anti-inflammatory properties, Nature Medicine, vol.72, issue.6, pp.698-701, 1999.
DOI : 10.1016/0003-2697(76)90527-3

N. Gupta, K. E. Brown, and A. H. Milam, Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration, Experimental Eye Research, vol.76, issue.4, pp.463-471, 2003.
DOI : 10.1016/S0014-4835(02)00332-9

G. S. Hageman, D. H. Anderson, L. V. Johnson, L. S. Hancox, A. J. Taiber et al., A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age, 2005.

S. J. Hu, B. Calippe, S. Lavalette, C. Roubeix, F. Montassar et al., Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1?? Secretion and Photoreceptor Neurodegeneration, Journal of Neuroscience, vol.35, issue.18, pp.6987-6996, 2015.
DOI : 10.1523/JNEUROSCI.3955-14.2015

P. T. Johnson, K. E. Betts, M. J. Radeke, G. S. Hageman, D. H. Anderson et al., Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid, Proc. Natl. Acad. Sci. USA 103, pp.17456-17461, 2006.

L. L. Jones and M. H. Tuszynski, Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors, J. Neurosci, vol.22, pp.4611-4624, 2002.

Y. H. Kang, B. C. Urban, R. B. Sim, and U. Kishore, Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells, Immunobiology, vol.217, issue.4, pp.455-464, 2012.
DOI : 10.1016/j.imbio.2011.10.008

A. Kopp, M. Hebecker, E. Svobodová, J. Zsi, and M. , Factor H: A Complement Regulator in Health and Disease, and a Mediator of Cellular Interactions, Biomolecules, vol.188, issue.1, pp.46-75, 2012.
DOI : 10.1007/s13238-011-1029-y

E. M. Lad, S. W. Cousins, J. S. Van-arnam, and A. D. Proia, Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.14, issue.Pt 4, pp.1941-1945, 2015.
DOI : 10.1089/ten.tea.2007.0264

O. Levy, S. Lavalette, S. J. Hu, M. Housset, W. Raoul et al., APOE isoforms control pathogenic subretinal inflammation in age, 2015.

H. Y. Lim, N. M?-uller, M. J. Herold, J. Van-den-brandt, R. et al., Glucocorticoids exert opposing effects on macrophage function dependent on their concentration, Immunology, vol.8, issue.1, pp.47-53, 2007.
DOI : 10.1210/me.2002-0305

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2007.02611.x/pdf

J. Losse, P. F. Zipfel, J. Zsi, and M. , Factor H and Factor H-Related Protein 1 Bind to Human Neutrophils via Complement Receptor 3, Mediate Attachment to Candida albicans, and Enhance Neutrophil Antimicrobial Activity, The Journal of Immunology, vol.184, issue.2, 2010.
DOI : 10.4049/jimmunol.0901702

C. Luo, M. Chen, and H. Xu, Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid, Mol. Vis, vol.17, pp.1588-1597, 2011.

P. P. Manna, J. Dimitry, P. A. Oldenborg, F. , and W. A. , CD47 Augments Fas/CD95-mediated Apoptosis, Journal of Biological Chemistry, vol.263, issue.33, pp.29637-29644, 2005.
DOI : 10.1023/A:1025598609965

URL : http://www.jbc.org/content/280/33/29637.full.pdf

M. Martin and A. M. Blom, Complement in removal of the dead - balancing inflammation, Immunological Reviews, vol.290, issue.Pt 4, pp.218-232, 2016.
DOI : 10.1074/jbc.M115.671180

D. Mastellos, J. Prechl, G. Lá-szló, K. Papp, E. Olá-h et al., Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays, Molecular Immunology, vol.40, issue.16, pp.1213-1221, 2004.
DOI : 10.1016/j.molimm.2003.10.019

H. Matsui, T. Ohgomori, T. Natori, K. Miyamoto, S. Kusunoki et al., Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis, Cell Death and Disease, vol.148, issue.12, p.946, 2013.
DOI : 10.1038/nn.3062

C. Nathan and A. Ding, Nonresolving Inflammation, Cell, vol.140, issue.6, pp.871-882, 2010.
DOI : 10.1016/j.cell.2010.02.029

URL : https://doi.org/10.1016/j.cell.2010.02.029

T. F. Ng and J. W. Streilein, Light-induced migration of retinal microglia into the subretinal space, Invest. Ophthalmol. Vis. Sci, vol.42, pp.3301-3310, 2001.

T. F. Ng, B. Turpie, and S. Masli, Thrombospondin-1???Mediated Regulation of Microglia Activation after Retinal Injury, Investigative Opthalmology & Visual Science, vol.50, issue.11, pp.5472-5478, 2009.
DOI : 10.1167/iovs.08-2877

M. C. Pickering, H. T. Cook, J. Warren, A. E. Bygrave, J. Moss et al., Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H, Nature Genetics, vol.33, issue.4, pp.424-428, 2002.
DOI : 10.4049/jimmunol.166.11.6820

A. J. Quesada, T. Nelius, R. Yap, T. A. Zaichuk, A. Alfranca et al., In vivo upregulation of CD95 and CD95L causes synergistic inhibition of angiogenesis by TSP1 peptide and metronomic doxorubicin treatment, Cell Death and Differentiation, vol.16, issue.6, pp.649-658, 2005.
DOI : 10.1161/01.RES.83.3.233

J. Rayes, M. J. Hollestelle, P. Legendre, I. Marx, P. G. De-groot et al., Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B, Blood, vol.115, issue.23, pp.4870-4877, 2010.
DOI : 10.1182/blood-2009-11-254193

J. Rayes, L. T. Roumenina, J. D. Dimitrov, Y. Repessé, M. Ing et al., The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status, Blood, vol.123, issue.1, pp.121-125, 2014.
DOI : 10.1182/blood-2013-04-495853

S. H. Sarks, Ageing and degeneration in the macular region: a clinico-pathological study., British Journal of Ophthalmology, vol.60, issue.5, pp.324-341, 1976.
DOI : 10.1136/bjo.60.5.324

G. Schlaf, T. Demberg, N. Beisel, H. L. Schieferdecker, and O. Gö-tze, Expression and regulation of complement factors H and I in rat and human cells: some critical notes, Molecular Immunology, vol.38, issue.2-3, pp.231-239, 2001.
DOI : 10.1016/S0161-5890(01)00045-1

D. Tedesco and L. Haragsim, Cyclosporine: A Review, Journal of Transplantation, vol.331, issue.9, 2012.
DOI : 10.1111/j.1742-7843.2008.00327.x

C. B. Toomey, U. Kelly, D. R. Saban, B. Rickman, and C. , Regulation of age-related macular degeneration-like pathology by complement factor H, Proc. Natl. Acad. Sci. USA, pp.3040-3049, 2015.
DOI : 10.1001/archopht.1994.01090150132035

S. Wang, C. M. Sorenson, and N. Sheibani, Lack of Thrombospondin 1 and Exacerbation of Choroidal Neovascularization, Archives of Ophthalmology, vol.130, issue.5, pp.615-620, 2012.
DOI : 10.1001/archopthalmol.2011.1892

D. Weismann, K. Hartvigsen, N. Lauer, K. L. Bennett, H. P. Scholl et al., Complement factor H binds malondialdehyde epitopes and protects from oxidative stress, Nature, vol.9, issue.7367, pp.76-81, 2011.
DOI : 10.1038/nm876

H. Wilms, M. A. Wollmer, and J. Sievers, In vitro-staining specificity of the antibody 5-D-4 for microglia but not for monocytes and macrophages indicates that microglia are a unique subgroup of the myelomonocytic lineage, Journal of Neuroimmunology, vol.98, issue.2, 1999.
DOI : 10.1016/S0165-5728(99)00066-1

W. L. Wong, X. Su, X. Li, C. M. Cheung, R. Klein et al., Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis, The Lancet Global Health, vol.2, issue.2, pp.106-116, 2014.
DOI : 10.1016/S2214-109X(13)70145-1

Z. Zhang, D. Yu, J. Yuan, Y. Guo, H. Wang et al., Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer, Cancer Epidemiology, vol.36, issue.2, pp.111-115, 2012.
DOI : 10.1016/j.canep.2011.11.004