O. Corti, S. Lesage, and A. Brice, What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease, Physiological Reviews, vol.91, issue.4, pp.1161-218, 2010.
DOI : 10.1152/physrev.00022.2010

B. Thomas and M. Beal, Parkinson's disease, Human Molecular Genetics, vol.16, issue.R2, pp.183-94, 2007.
DOI : 10.1093/hmg/ddm159

J. Jankovic, Parkinson's disease: clinical features and diagnosis, Journal of Neurology, Neurosurgery & Psychiatry, vol.79, issue.4, pp.368-76, 2008.
DOI : 10.1136/jnnp.2007.131045

V. Bonifati, Genetics of Parkinson's disease ??? state of the art, 2013, Parkinsonism & Related Disorders, vol.20, issue.13, pp.23-31, 2013.
DOI : 10.1016/S1353-8020(13)70009-9

M. Lin and M. Farrer, Genetics and genomics of Parkinson???s disease, Genome Medicine, vol.6, issue.6, 2014.
DOI : 10.1186/gm566

L. Kilarski, J. Pearson, V. Newsway, E. Majounie, M. Knipe et al., in early-onset Parkinson's disease, Movement Disorders, vol.25, issue.12, pp.1522-1531, 2012.
DOI : 10.1002/mds.23221

S. Edvardson, Y. Cinnamon, A. Ta-shma, A. Shaag, Y. Yim et al., A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrinuncoating co-chaperone auxilin, is associated with juvenile parkinsonism, PLoS One, 2012.

J. Clarimón and J. Kulisevsky, Parkinson's Disease: From Genetics to Clinical Practice, Current Genomics, vol.14, issue.8, pp.560-567, 2013.
DOI : 10.2174/1389202914666131210212305

S. Lesage, V. Drouet, E. Majounie, V. Deramecourt, M. Jacoupy et al., Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1
URL : https://hal.archives-ouvertes.fr/hal-01289266

S. Sudhaman, K. Prasad, M. Behari, U. Muthane, R. Juyal et al., Discovery of a frameshift mutation in podocalyxin-like (PODXL) gene, coding for a neural adhesion molecule, as causal for autosomal-recessive juvenile Parkinsonism, Journal of Medical Genetics, vol.133, issue.(Database issue), pp.450-456, 2016.
DOI : 10.1007/s00439-014-1462-0

S. Asakawa, K. Tsunematsu, A. Takayanagi, T. Sasaki, A. Shimizu et al., The Genomic Structure and Promoter Region of the Human Parkin Gene, Biochemical and Biophysical Research Communications, vol.286, issue.5, pp.863-871, 2001.
DOI : 10.1006/bbrc.2001.5490

C. Lücking, A. Dürr, V. Bonifati, J. Vaughan, D. Michele et al., Gene, New England Journal of Medicine, vol.342, issue.21, pp.1560-714, 2000.
DOI : 10.1056/NEJM200005253422103

A. Pickrell and R. Youle, The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson???s Disease, Neuron, vol.85, issue.2, pp.257-73, 2015.
DOI : 10.1016/j.neuron.2014.12.007

E. Steer, M. Dail, and C. Chu, Beyond Mitophagy: Cytosolic PINK1 as a Messenger of Mitochondrial Health, Antioxidants & Redox Signaling, vol.22, issue.12, 2015.
DOI : 10.1089/ars.2014.6206

C. Klein and A. Westenberger, Genetics of Parkinson's disease. Cold Spring Harb Perspect Med, 2012.

D. Hernandez, X. Reed, and A. Singleton, Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance, Journal of Neurochemistry, vol.89, issue.3 Pt 1, pp.59-74, 2016.
DOI : 10.1016/j.ajhg.2011.06.008

URL : http://onlinelibrary.wiley.com/doi/10.1111/jnc.13593/pdf

L. Scott, V. Dawson, and T. Dawson, Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes, Experimental Neurology, vol.298, 2017.
DOI : 10.1016/j.expneurol.2017.04.008

C. Lill, Genetics of Parkinson's disease, Molecular and Cellular Probes, vol.30, issue.6, pp.386-96, 2016.
DOI : 10.1016/j.mcp.2016.11.001

C. Schulte and T. Gasser, Genetic basis of Parkinson's disease: inheritance, penetrance, and expression, Appl Clin Genet, vol.4, pp.67-80, 2011.

H. Yoshino, H. Tomiyama, N. Tachibana, K. Ogaki, Y. Li et al., Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism, Neurology, vol.75, issue.15, pp.1356-61, 2010.
DOI : 10.1212/WNL.0b013e3181f73649

D. Fonzo, A. Dekker, M. Montagna, P. Baruzzi, A. Yonova et al., FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome, Neurology, vol.72, issue.3, 2009.
DOI : 10.1212/01.wnl.0000338144.10967.2b

Ç. Köro?lu, L. Baysal, M. Cetinkaya, H. Karasoy, and A. Tolun, DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability, Parkinsonism & Related Disorders, vol.19, issue.3, 2013.
DOI : 10.1016/j.parkreldis.2012.11.006

C. Popescu, Mechanisms Implicated in Parkinson Disease from Genetic Perspective, Medical & Clinical Reviews, vol.2, issue.3, 2016.
DOI : 10.21767/2471-299X.1000028

C. Krebs, S. Karkheiran, J. Powell, M. Cao, V. Makarov et al., Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures, Human Mutation, vol.280, issue.5, pp.1200-1207, 2013.
DOI : 10.1074/jbc.M407724200

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790461/pdf

M. Quadri, M. Fang, M. Picillo, S. Olgiati, G. Breedveld et al., Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism, Human Mutation, vol.89, issue.1, pp.1208-1223, 2013.
DOI : 10.1016/j.ajhg.2011.06.008

K. Chen, R. Wu, H. Lin, C. Tai, and C. Lin, Mutational analysis of SYNJ1 gene (PARK20) in Parkinson's disease in a Taiwanese population, Neurobiology of Aging, vol.36, issue.10, pp.7-8, 2015.
DOI : 10.1016/j.neurobiolaging.2015.06.009

A. Hughes, S. Daniel, L. Kilford, and A. Lees, Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases., Journal of Neurology, Neurosurgery & Psychiatry, vol.55, issue.3, pp.181-185, 1992.
DOI : 10.1136/jnnp.55.3.181

H. Bouhouche, H. Tibar, B. E. Haj, R. , E. Bayad et al., G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson???s Disease, Parkinson's Disease, vol.2, issue.6, article 48, 2017.
DOI : 10.1001/jamaneurol.2014.2704

URL : http://doi.org/10.1155/2017/2412486

H. Li and R. Durbin, Fast and accurate long-read alignment with Burrows???Wheeler transform, Bioinformatics, vol.26, issue.5, pp.589-95, 2010.
DOI : 10.1093/bioinformatics/btp698

URL : https://academic.oup.com/bioinformatics/article-pdf/26/5/589/16896917/btp698.pdf

A. Mckenna, M. Hanna, E. Banks, A. Sivachenko, K. Cibulskis et al., The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data, Genome Research, vol.20, issue.9, pp.1297-303, 2010.
DOI : 10.1101/gr.107524.110

K. Wang, M. Li, and H. Hakonarson, ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data, Nucleic Acids Research, vol.38, issue.16, 2010.
DOI : 10.1093/nar/gkq603

J. Mitsui, Y. Takahashi, J. Goto, H. Tomiyama, S. Ishikawa et al., Mechanisms of Genomic Instabilities Underlying Two Common Fragile-Site-Associated Loci, PARK2 and DMD, in Germ Cell and Cancer Cell Lines, The American Journal of Human Genetics, vol.87, issue.1, pp.75-89, 2010.
DOI : 10.1016/j.ajhg.2010.06.006

S. Morais, R. Bastos-ferreira, J. Sequeiros, and I. Alonso, Genomic mechanisms underlying PARK2 large deletions identified in a cohort of patients with PD, Neurol Genet, 2016.

J. Clarimon, J. Johnson, O. Dogu, W. Horta, N. Khan et al., Defining the ends of Parkin exon 4 deletions in two different families with Parkinson's disease, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol.343, issue.1, pp.120-123, 2005.
DOI : 10.1002/ajmg.b.30119

W. Ambroziak, D. Koziorowski, K. Duszyc, P. Górka-skoczylas, A. Potulska-chromik et al., Genomic instability in the PARK2 locus is associated with Parkinson???s disease, Journal of Applied Genetics, vol.41, issue.6, pp.451-61, 2015.
DOI : 10.1038/ng.399

B. El-haj, R. Regragui, W. Tazi-ahnini, R. Skalli, A. Bouslam et al., A novel homozygous p.L539F mutation identified in PINK1 gene in a Moroccan patient with parkinsonism, Biomed Res Int, p.3460234, 2016.

X. Yang and Y. Xu, Mutations in the ATP13A2 gene and parkinsonism: a preliminary review, Biomed Res Int, p.371256, 2014.

C. Paisan-ruiz, R. Guevara, M. Federoff, H. Hanagasi, F. Sina et al., Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations, Movement Disorders, vol.18, issue.12, pp.1791-800, 2010.
DOI : 10.1111/j.1468-1331.1995.tb00088.x

M. Picillo, A. Ranieri, G. Orefice, V. Bonifati, and P. Barone, Clinical progression of SYNJ1-related early onset atypical parkinsonism: 3-year follow up of the original Italian family, Journal of Neurology, vol.34, issue.9, pp.823-827, 2014.
DOI : 10.1002/humu.22372