Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Abstract : Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA B-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.
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Nature Communications, Nature Publishing Group, 2017, 8, pp.1135. 〈10.1038/s41467-017-01192-1〉
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Anna Tchenio, Salvatore Lecca, Kristina Valentinova, Manuel Mameli. Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms. Nature Communications, Nature Publishing Group, 2017, 8, pp.1135. 〈10.1038/s41467-017-01192-1〉. 〈hal-01633963〉

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