Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants

Abstract : Background: Adipose tissue (AT) is involved in several physiological functions, including metabolic regulation, energy storage, and endocrine functions. Objectives: In this review we examined the evidence that an additional function of AT is to modulate persistent organic pollutant (POP) toxicity through several mechanisms. Methods: We reviewed the literature on the interaction of AT with POPs to provide a comprehensive model for this additional function of AT. Discussion: As a storage compartment for lipophilic POPs, AT plays a critical role in the toxicokinetics of a variety of drugs and pollutants, in particular, POPs. By sequestering POPs, AT can protect other organs and tissues from POPs overload. However, this protective function could prove to be a threat in the long run. The accumulation of lipophilic POPs will increase total body burden. These accumulated POPs are slowly released into the bloodstream, and more so during weight loss. Thus, AT constitutes a continual source of internal exposure to POPs. In addition to its buffering function, AT is also a target of POPs and may mediate part of their metabolic effects. This is particularly relevant because many POPs induce obesogenic effects that may lead to quantitative and qualitative alterations of AT. Some POPs also induce a proinflammatory state in AT, which may lead to detrimental metabolic effects. Conclusion: AT appears to play diverse functions both as a modulator and as a target of POPs toxicity.
Type de document :
Article dans une revue
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2013, 121 (2), pp.162-169. 〈10.1289/ehp.1205485〉
Liste complète des métadonnées

Littérature citée [100 références]  Voir  Masquer  Télécharger

http://hal.upmc.fr/hal-01549161
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : mercredi 28 juin 2017 - 15:47:25
Dernière modification le : jeudi 11 janvier 2018 - 06:20:15
Document(s) archivé(s) le : mercredi 17 janvier 2018 - 22:44:47

Fichier

ehp.1205485.pdf
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

Michele La Merrill, Claude Emond, Min Ji Kim, Jean-Philippe Antignac, Bruno Le Bizec, et al.. Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2013, 121 (2), pp.162-169. 〈10.1289/ehp.1205485〉. 〈hal-01549161〉

Partager

Métriques

Consultations de la notice

156

Téléchargements de fichiers

71