Plasmodium P36 determines host cell receptor usage during sporozoite invasion

Abstract : Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.
Type de document :
Article dans une revue
eLife, eLife Sciences Publication, 2017, 6, pp.e25903. 〈10.7554/eLife.25903〉
Liste complète des métadonnées

Littérature citée [81 références]  Voir  Masquer  Télécharger
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : mercredi 5 juillet 2017 - 11:39:34
Dernière modification le : lundi 15 janvier 2018 - 16:26:01
Document(s) archivé(s) le : mardi 23 janvier 2018 - 20:28:48


Publication financée par une institution


Distributed under a Creative Commons Paternité 4.0 International License




Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, et al.. Plasmodium P36 determines host cell receptor usage during sporozoite invasion. eLife, eLife Sciences Publication, 2017, 6, pp.e25903. 〈10.7554/eLife.25903〉. 〈hal-01556552〉



Consultations de la notice


Téléchargements de fichiers